ArticleAlcoholism, clinical and experimental research2009
The interaction of reward genes with environmental factors in contribution to alcoholism in mexican americans.
Article in Alcoholism, clinical and experimental research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Pooled it
- The association between the SLC6A3 VNTR 9-repeat allele and alcoholism-a meta-analysis.Alcoholism, clinical and experimental research · 2011Pooled it
- Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse.The Canadian journal of addiction · 2019Article
- A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.The American journal on addictions · 2018Review
- Review: Environmental influences on alcohol use: Informing research on the joint effects of genes and the environment in diverse U.S. populations.The American journal on addictions · 2017Review
- Interrelationship between family history of alcoholism and generational status in the prediction of alcohol dependence in US Hispanics.Psychological medicine · 2017Article
- Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions.Molecular neurobiology · 2015Article
- Dopaminergic genes modulate response inhibition in alcohol abusing adults.Addiction biology · 2012Article
- Nur-related receptor 1 gene polymorphisms and alcohol dependence in Mexican Americans.World journal of gastroenterology · 2012Article
- Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: the example of alcohol use promoting peers and μ-opioid receptor M1 variation.Development and psychopathology · 2012Article
- Assessing gene-gene interactions in pharmacogenomics.Molecular diagnosis & therapy · 2012Review
- The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review.Clinical psychology review · 2011Review
- OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.Drug and alcohol dependence · 2010Review
- Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development.Genetics and molecular biologyArticle
- μ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption.Alcohol and alcoholism (Oxford, Oxfordshire)Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundAlcoholism is a polygenic disorder resulting from reward deficiency; polymorphisms in reward genes including serotonin transporter (5-HTT)-linked polymorphic region (5-HTTLPR), A118G in opioid receptor mu1 (OPRM1), and -141C Insertion/Deletion (Ins/Del) in dopamine receptor D2 (DRD2) as well as environmental factors (education and marital status) might affect the risk of alcoholism. Objective of the current study was to examine the main and interacting effect of these 3 polymorphisms and 2 environmental factors in contribution to alcoholism in Mexican Americans.
methodsGenotyping of 5-HTTLPR, OPRM1 A118G, and DRD2-141C Ins/Del was performed in 365 alcoholics and 338 nonalcoholic controls of Mexican Americans who were gender- and age-matched. Alcoholics were stratified according to tertiles of MAXDRINKS, which denotes the largest number of drinks consumed in one 24-hour period. Data analysis was done in the entire data set and in each alcoholic stratum. Multinomial logistic regression was conducted to explore the main effect of 3 polymorphisms and 2 environmental factors (education and marital status); classification tree, generalized multifactor dimensionality reduction (GMDR) analysis, and polymorphism interaction analysis version 2.0 (PIA 2) program were used to study factor interaction.
resultsMain effect of education, OPRM1, and DRD2 was detected in alcoholic stratum of moderate and/or largest MAXDRINKS with education < or =12 years, OPRM1 118 A/A, and DRD2 -141C Ins/Ins being risk factors. Classification tree analysis, GMDR analysis, and PIA 2 program all supported education*OPRM1 interaction in alcoholics of largest MAXDRINKS with education < or =12 years coupled with OPRM1 A/A being a high risk factor; dendrogram showed synergistic interaction between these 2 factors; dosage-effect response was also observed for education*OPRM1 interaction. No definite effect of marital status and 5-HTTLPR in pathogenesis of alcoholism was observed.
conclusionsOur results suggest main effect of education background, OPRM1 A118G, and DRD2 -141C Ins/Del as well as education*OPRM1 interaction in contribution to moderate and/or severe alcoholism in Mexican Americans. Functional relevance of these findings still needs to be explored.
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