ArticleAnnals of biomedical engineering2009
Myofiber ellipticity as an explanation for transverse asymmetry of skeletal muscle diffusion MRI in vivo signal.
Article in Annals of biomedical engineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
- Time-dependent diffusion in skeletal muscle with the random permeable barrier model (RPBM): application to normal controls and chronic exertional compartment syndrome patients.NMR in biomedicine · 2014Trial
- Relationships between diffusion tensor parameters and measures of skeletal muscle fiber size and strength after anterior cruciate ligament injury.Magnetic resonance imaging · 2025Article
- Evaluation of skeletal muscle microcirculation via magnetic resonance intravoxel incoherent motion perfusion imaging in an acute ischemia rabbit model.Quantitative imaging in medicine and surgery · 2025Article
- Multiparametric MRI Assessment of Morpho-Functional Muscle Changes Following a 6-Month FES-Cycling Training Program: Pilot Study in People With a Complete Spinal Cord Injury.JMIR rehabilitation and assistive technologies · 2025Article
- Accelerated, Physics-Inspired Inference of Skeletal Muscle Microstructure From Diffusion-Weighted MRI.IEEE transactions on medical imaging · 2024Article
- Magnetic Resonance Imaging Biomarkers of Muscle.Tomography (Ann Arbor, Mich.) · 2024Review
- Changes in lumbar muscle diffusion tensor indices with age.BJR open · 2024Article
- Time-dependent diffusion tensor imaging and diffusion modeling of age-related differences in the medial gastrocnemius and feasibility study of correlations to histopathology.NMR in biomedicine · 2023Article
- Double pulsed field gradient diffusion MRI to assess skeletal muscle microstructure.Magnetic resonance in medicine · 2023Article
- Article
- Application of diffusion microstructure imaging in musculoskeletal radiology - translation from head to shoulders.European radiology · 2023Article
- Diffusion MRI fiber diameter for muscle denervation assessment.Quantitative imaging in medicine and surgery · 2022Article
- Diffusion tensor imaging indices of acute muscle damage are augmented after exercise in peripheral arterial disease.European journal of applied physiology · 2021Article
- Varying diffusion time to discriminate between simulated skeletal muscle injury models using stimulated echo diffusion tensor imaging.Magnetic resonance in medicine · 2021Article
- Differences between muscle from osteoporotic and osteoarthritic subjects: in vitro study by diffusion-tensor MRI and histological findings.Aging clinical and experimental research · 2020Article
- Diffusion tensor imaging combined with T2 mapping to quantify changes in the skeletal muscle associated with training and endurance exercise in competitive triathletes.European radiology · 2020Article
- Role of the Extracellular Matrix in Loss of Muscle Force With Age and Unloading Using Magnetic Resonance Imaging, Biochemical Analysis, and Computational Models.Frontiers in physiology · 2020Review
- Monitoring of diffusion properties and transverse relaxation time of mouse ischaemic muscle after administration of human mesenchymal stromal cells derived from adipose tissue.Cell proliferation · 2019Article
- Paraspinal Muscle DTI Metrics Predict Muscle Strength.Journal of magnetic resonance imaging : JMRI · 2019Article
- Diffusion tensor imaging and diffusion modeling: Application to monitoring changes in the medial gastrocnemius in disuse atrophy induced by unilateral limb suspension.Journal of magnetic resonance imaging : JMRI · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Due to its unique non-invasive microstructure probing capabilities, diffusion tensor imaging (DTI) constitutes a valuable tool in the study of fiber orientation in skeletal muscles. By implementing a DTI sequence with judiciously chosen directional encoding to quantify in vivo the microarchitectural properties in the calf muscles of three healthy volunteers at rest, we report that the secondary eigenvalue is significantly higher than the tertiary eigenvalue, a phenomenon corroborated by prior DTI findings. Toward a physics-based explanation of this phenomenon, we propose a composite medium model that accounts for water diffusion in the space within the muscle fiber and the extracellular space. The muscle fibers are abstracted as cylinders of infinite length with an elliptical cross section, the latter closely approximating microstructural features well documented in prior histological studies of excised muscle. The range of values of fiber ellipticity predicted by our model agrees with these studies, and the spatial orientation of the cross-sectional ellipses is consistent with local muscle strain fields and the putative direction of lateral transmission of stress between fibers in certain regions in three antigravity muscles (Tibialis Anterior, Soleus, and Gastrocnemius), as well as independent measurements of deformation in active calf muscles. As a metric, fiber cross-sectional ellipticity may be useful for quantifying morphological changes in skeletal muscle fibers with aging, hypertrophy, or sarcopenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.