Evidence map›Paper›PMID 19763581›Full record

ArticleEuropean radiology2010

Imaging of adult astrocytic brain tumours with 7 T MRI: preliminary results.

Christoph Moenninghoff, Stefan Maderwald, Jens M Theysohn, Oliver Kraff, Mark E Ladd, Nicolai El Hindy, Johannes van de Nes, Michael Forsting, Isabel Wanke

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02062372 (Spatial Analysis and Validation of Glioblastoma on 7 T MRI), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02062372 naterminatednot on this mapstarted 2014, after this paper: background citation

Spatial Analysis and Validation of Glioblastoma on 7 T MRI

TypeinterventionalSponsorMaastricht Radiation OncologyRan2014 to 2018Enrolled5ConditionsGlioblastomaArms7 T MRI, Biopsy
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
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  12. Experience with 7.0 T MRI in Patients with Supratentorial Meningiomas.Journal of Korean Neurosurgical Society · 2016
    Article
  13. Article
  14. Review
  15. Article
  16. Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases.Journal of controlled release : official journal of the Controlled Release Society · 2013
    Article
  17. Article
  18. Anaplastic astrocytoma.Current treatment options in neurology · 2013
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Christoph MoenninghoffDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany. christoph.moenninghoff@uk-essen.de
Stefan Maderwald
Jens M Theysohn
Oliver Kraff
Mark E Ladd
Nicolai El Hindy
Johannes van de Nes
Michael Forsting
Isabel Wanke
Essen University Hospital · DEErwin L. Hahn Institute for Magnetic Resonance Imaging · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this study tumour vascularity and necrosis of intracranial astrocytomas were compared using 7 T and 1.5 T magnetic resonance imaging (MRI).

methodsFifteen patients with histologically proven astrocytomas (WHO grades II-IV) were prospectively examined at 1.5 T (Magnetom Espree or Sonata) and 7 T (Magnetom 7 T, Siemens, Erlangen, Germany) with T2*-w (weighted), T1-w with (only a subset of five patients at 7 T) and without contrast medium, T2-w and proton-density (PD)-w MRI. Clinically used 1.5 T sequences were adapted to 7 T. Histological findings and T2*-w MR images at both field strengths were compared for the presence of assumed tumour microvascularity and necrosis. Two diffusely infiltrating astrocytomas, four anaplastic astrocytomas and nine glioblastomas were included.

resultsT2*-w images depicted susceptibility patterns representing presumed tumour microvascularity in 8 out of 15 (53%) gliomas at 7 T compared with 5 out of 15 (33%) gliomas at 1.5 T. Compared with 1.5 T MRI three additional necrotic tumour areas were depicted only on 7 T T2- and T2*-w images of one glioblastoma. On T1-w MR images, contrast enhancement of five out of five glioblastomas was similar at both field strengths.

conclusion7 T gradient-echo sequences provide excellent image contrast of presumed microvasculature and necrosis in astrocytomas.

Indexed as

AdultAgedAstrocytomaBrain NeoplasmsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeovascularization, PathologicPilot ProjectsReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID19763581
OpenAlexW2002396011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.