ArticlePloS one2009
Time-resolved transcriptome analysis of Bacillus subtilis responding to valine, glutamate, and glutamine.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Transcriptomic analyses of bacterial growth on fungal necromass reveal different microbial community niches during degradation.Applied and environmental microbiology · 2024Article
- Understanding and application of Bacillus nitrogen regulation: A synthetic biology perspective.Journal of advanced research · 2023Review
- Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2.Microbial cell factories · 2021Article
- Microbial single-cell RNA sequencing by split-pool barcoding.Science (New York, N.Y.) · 2021Article
- Identification of a Genetically Linked but Functionally Independent Two-Component System Important for Cell Division of the Rice PathogenFrontiers in microbiology · 2021Article
- The Functional 3D Organization of Unicellular Genomes.Scientific reports · 2019Article
- Production of pikromycin using branched chain amino acid catabolism in Streptomyces venezuelae ATCC 15439.Journal of industrial microbiology & biotechnology · 2018Article
- The Synergistic Effect of Exogenous Glutamine and Rifampicin AgainstFrontiers in microbiology · 2018Article
- Transcriptional Profiling Analysis of Bacillus subtilis in Response to High Levels of Fe(3.).Current microbiology · 2016Article
- Genome-wide mapping of TnrA-binding sites provides new insights into the TnrA regulon in Bacillus subtilis.MicrobiologyOpen · 2015Article
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- A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis.Molecular microbiology · 2011Article
- Comparative transcriptome analysis of Bacillus subtilis responding to dissolved oxygen in adenosine fermentation.PloS one · 2011Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microorganisms can restructure their transcriptional output to adapt to environmental conditions by sensing endogenous metabolite pools. In this paper, an Agilent customized microarray representing 4,106 genes was used to study temporal transcript profiles of Bacillus subtilis in response to valine, glutamate and glutamine pulses over 24 h. A total of 673, 835, and 1135 amino-acid-regulated genes were identified having significantly changed expression at one or more time points in response to valine, glutamate, and glutamine, respectively, including genes involved in cell wall, cellular import, metabolism of amino-acids and nucleotides, transcriptional regulation, flagellar motility, chemotaxis, phage proteins, sporulation, and many genes of unknown function. Different amino acid treatments were compared in terms of both the global temporal profiles and the 5-minute quick regulations, and between-experiment differential genes were identified. The highlighted genes were analyzed based on diverse sources of gene functions using a variety of computational tools, including T-profiler analysis, and hierarchical clustering. The results revealed the common and distinct modes of action of these three amino acids, and should help to elucidate the specific signaling mechanism of each amino acid as an effector.
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