ArticleJournal of porphyrins and phthalocyanines2008
Design of Metalloporphyrin-Based Dendritic Nanoprobes for Two-Photon Microscopy of Oxygen.
Article in Journal of porphyrins and phthalocyanines, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Geometrical and Electronic Structure of Fluorinated and Non-Fluorinated Platinum(II) Tetraphenylporphyrin Complexes.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia.Nature reviews. Immunology · 2025Review
- Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia.Clinical epigenetics · 2023Review
- The Challenges of OInternational journal of molecular sciences · 2022Review
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Quantitative Mapping of Liver Hypoxia in Living Mice Using Time-Resolved Wide-Field Phosphorescence Lifetime Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Cerebrovascular Blood Flow Design and Regulation; Vulnerability in Aging Brain.Frontiers in physiology · 2020Review
- Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair.ACS applied materials & interfaces · 2019Article
- Imaging of oxygen and hypoxia in cell and tissue samples.Cellular and molecular life sciences : CMLS · 2018Review
- Coumarin-Tetrapyrrolic Macrocycle Conjugates: Synthesis and Applications.Molecules (Basel, Switzerland) · 2017Review
- Two-Photon Absorbing Phosphorescent Metalloporphyrins: Effects of π-Extension and Peripheral Substitution.Journal of the American Chemical Society · 2016Article
- The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Ratiometric Molecular Probes Based on Dual Emission of a Blue Fluorescent Coumarin and a Red Phosphorescent Cationic Iridium(III) Complex for Intracellular Oxygen Sensing.Sensors (Basel, Switzerland) · 2015Article
- Two-photon antenna-core oxygen probe with enhanced performance.Analytical chemistry · 2014Article
- Article
- Three-dimensional mapping of oxygen tension in cortical arterioles before and after occlusion.Biomedical optics express · 2013Article
- Optical probes and techniques for O2 measurement in live cells and tissue.Cellular and molecular life sciences : CMLS · 2012Review
- Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain.Journal of medicinal chemistry · 2011Article
- "Overshoot" of O₂ is required to maintain baseline tissue oxygenation at locations distal to blood vessels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Two-photon microscopy of oxygen: polymersomes as probe carrier vehicles.The journal of physical chemistry. B · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Metalloporphyrin-based phosphorescent nanoprobes are being developed for two-photon microscopy of oxygen. In these molecular constructs generation of porphyrin triplet states upon two-photon excitation is induced upon the intramolecular Förster-type resonance energy transfer from a covalently attached 2P antenna. In the earlier developed prototypes, electron transfer between the antenna and the metalloporphyrin strongly interfered with the phosphorescence, reducing the sensitivity and the dynamic range of the sensors. By tuning the distances between the antenna and the core and adjusting their redox potentials the unwanted electron transfer could be prevented. An array of phosphorescent Pt porphyrins (energy transfer acceptors) and 2P dyes (energy transfer donors) was screened using dynamic quenching of phosphorescence, and the FRET-pair with the minimal ET rate was identified. This pair, consisting of Coumarin-343 and Pt meso-tetra-(4-alkoxyphenyl)porphyrin, was used to construct a probe in which the antenna fragments were linked to the termini of G3 poly(arylglycine) (AG) dendrimer with PtP core. The folded dendrimer formed an insulating layer between the porphyrin and the antenna, simultaneously controlling the rate of oxygen quenching (Stern-Volmer oxygen quenching constant). Modification of the dendrimer periphery with oligoethyleneglycol residues made the probe's signal insensitive to the presence of proteins and other macromolecular solutes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.