ArticlePLoS genetics2009
Meiotic recombination in human oocytes.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 112 citations in OpenAlex.
- Use of Cumulative Live Birth Rate per Total Number of Embryos to Calculate the Success of IVF in Consecutive IVF Cycles in Women Aged ≥35 Years.BioMed research international · 2019Trial
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
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- Meiotic pairing through barcode-like satellite DNA repeats.Nature communications · 2026Article
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- Human acrocentric chromosome short armbioRxiv : the preprint server for biology · 2025Article
- Healthy live birth after microsurgical enucleation of tripronuclear human zygote derived from ICSI: a case report.Journal of ovarian research · 2025Article
- Chromosomal Abnormalities in Miscarriages and Maternal Age: New Insights from the Study of 7118 Cases.Cells · 2024Article
- Oocyte Casein kinase 1α deletion causes defects in primordial follicle formation and oocyte loss by impairing oocyte meiosis and enhancing autophagy in developing mouse ovary.Cell death discovery · 2022Article
- Mouse oocytes carrying metacentric Robertsonian chromosomes have fewer crossover sites and higher aneuploidy rates than oocytes carrying acrocentric chromosomes alone.Scientific reports · 2022Article
- Article
- Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline.Molecular biology and evolution · 2022Article
- Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies.Cancers · 2021Review
- Genome diversity and instability in human germ cells and preimplantation embryos.Seminars in cell & developmental biology · 2021Article
- Which ovarian reserve marker relates to embryo quality on day 3 and blastocyst; age, AFC, AMH?JBRA assisted reproduction · 2021Article
- Failure to recombine is a common feature of human oogenesis.American journal of human genetics · 2021Article
- Higher Intercellular Variation in Genome-Wide Recombination Rate in Female Mice.Cytogenetic and genome research · 2021Article
- Crossover Interference, Crossover Maturation, and Human Aneuploidy.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- The pericentromeric heterochromatin of homologous chromosomes remains associated after centromere pairing dissolves in mouse spermatocyte meiosis.Chromosoma · 2019Article
- Shugoshin protects centromere pairing and promotes segregation of nonexchange partner chromosomes in meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
Studies of human trisomies indicate a remarkable relationship between abnormal meiotic recombination and subsequent nondisjunction at maternal meiosis I or II. Specifically, failure to recombine or recombination events located either too near to or too far from the centromere have been linked to the origin of human trisomies. It should be possible to identify these abnormal crossover configurations by using immunofluorescence methodology to directly examine the meiotic recombination process in the human female. Accordingly, we initiated studies of crossover-associated proteins (e.g., MLH1) in human fetal oocytes to analyze their number and distribution on nondisjunction-prone human chromosomes and, more generally, to characterize genome-wide levels of recombination in the human female. Our analyses indicate that the number of MLH1 foci is lower than predicted from genetic linkage analysis, but its localization pattern conforms to that expected for a crossover-associated protein. In studies of individual chromosomes, our observations provide evidence for the presence of "vulnerable" crossover configurations in the fetal oocyte, consistent with the idea that these are subsequently translated into nondisjunctional events in the adult oocyte.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.