ArticlePLoS genetics2009
Fast growth increases the selective advantage of a mutation arising recurrently during evolution under metal limitation.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 91 citations in OpenAlex.
- Module-Selection Balance in the Evolution of Modular Organisms.bioRxiv : the preprint server for biology · 2026Article
- Integrated genomic and transcriptomic Insights into methanol tolerance mechanisms in Methylobacterium extorquens AM1, identifying key targets for strain engineering.Journal of biological engineering · 2025Article
- Environmental modulation of global epistasis in a drug resistance fitness landscape.Nature communications · 2023Article
- Epistasis and evolution: recent advances and an outlook for prediction.BMC biology · 2023Review
- Global epistasis on fitness landscapes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Mutational robustness changes during long-term adaptation in laboratory budding yeast populations.eLife · 2022Article
- A Periplasmic Lanthanide Mediator, Lanmodulin, inFrontiers in microbiology · 2022Article
- Genetic Context Significantly Influences the Maintenance and Evolution of Degenerate Pathways.Genome biology and evolution · 2021Article
- Reasons for 2-furaldehyde and 5-hydroxymethyl-2-furaldehyde resistance in Saccharomyces cerevisiae: current state of knowledge and perspectives for further improvements.Applied microbiology and biotechnology · 2021Review
- Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function.The Journal of biological chemistry · 2020Article
- Patterns and Mechanisms of Diminishing Returns from Beneficial Mutations.Molecular biology and evolution · 2019Article
- Article
- Instability of the 16S rRNA methyltransferase-encoding npmA gene: why have bacterial cells possessing npmA not spread despite their high and broad resistance to aminoglycosides?The Journal of antibiotics · 2018Article
- Different adaptive strategies in E. coli populations evolving under macronutrient limitation and metal ion limitation.BMC evolutionary biology · 2018Article
- Effects of Beneficial Mutations in pykF Gene Vary over Time and across Replicate Populations in a Long-Term Experiment with Bacteria.Molecular biology and evolution · 2018Article
- Regulation of solvent tolerance in Pseudomonas putida S12 mediated by mobile elements.Microbial biotechnology · 2017Article
- Hitchhiking and epistasis give rise to cohort dynamics in adapting populations.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Transposable Elements Mediate Adaptive Debilitation of Flagella in Experimental Escherichia coli Populations.Journal of molecular evolution · 2017Article
- Hopanoid-free Methylobacterium extorquens DM4 overproduces carotenoids and has widespread growth impairment.PloS one · 2017Article
- Identification of the potentiating mutations and synergistic epistasis that enabled the evolution of inter-species cooperation.PloS one · 2017Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Understanding the evolution of biological systems requires untangling the molecular mechanisms that connect genetic and environmental variations to their physiological consequences. Metal limitation across many environments, ranging from pathogens in the human body to phytoplankton in the oceans, imposes strong selection for improved metal acquisition systems. In this study, we uncovered the genetic and physiological basis of adaptation to metal limitation using experimental populations of Methylobacterium extorquens AM1 evolved in metal-deficient growth media. We identified a transposition mutation arising recurrently in 30 of 32 independent populations that utilized methanol as a carbon source, but not in any of the 8 that utilized only succinate. These parallel insertion events increased expression of a novel transporter system that enhanced cobalt uptake. Such ability ensured the production of vitamin B(12), a cobalt-containing cofactor, to sustain two vitamin B(12)-dependent enzymatic reactions essential to methanol, but not succinate, metabolism. Interestingly, this mutation provided higher selective advantages under genetic backgrounds or incubation temperatures that permit faster growth, indicating growth-rate-dependent epistatic and genotype-by-environment interactions. Our results link beneficial mutations emerging in a metal-limiting environment to their physiological basis in carbon metabolism, suggest that certain molecular features may promote the emergence of parallel mutations, and indicate that the selective advantages of some mutations depend generically upon changes in growth rate that can stem from either genetic or environmental influences.
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