Evidence map›Paper›PMID 19763051›Full record

ReviewAnnals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia2009

A translational approach to lung cancer research: From EGFRs to Wnt and cancer stem cells.

Adam Yagui-Beltrán, David M Jablons

Abstract readReview
In one paragraph

Review in Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy.Current medicinal chemistry · 2019
    Review
  4. Article
  5. Oncogenic roles and drug target of CXCR4/CXCL12 axis in lung cancer and cancer stem cell.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adam Yagui-BeltránDepartment of Surgery, The University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, 94143, USA.
David M Jablons
UCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Inflammation and Lung CarcinogenesisR01CA132566 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COUSSENS, LISA M., JABLONS, DAVID M. · 2008 to 2012
$1.4M
The Wnt Pathway in Malignant MesotheliomaR01CA093708 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JABLONS, DAVID M. · 2005 to 2008
$883k
NCI NIH HHS R011R01CA093708-01A3NCI NIH HHS R01 CA093708NCI NIH HHS R01 CA132566
6 · The paper itself

Abstract

Lung cancer remains the main cause of all cancer deaths in the United States. The prognosis for non-small cell lung cancer, despite advances in current therapies, is disappointing. Fortunately, we are steadily gaining significant insights into the heterogeneous molecular pathogenesis of lung cancer, which seems to occur in a stepwise manner, mainly secondary to tobacco smoking. With the emerging power of gene expression signatures for individual lung tumors and with the advancing field of stem cell biology and the paradigm of cancer stem cells, we are most certainly paving the way to developing novel tools for the early detection, chemoprevention, and treatment of these vastly morbid pathologies with enormous global burden. We will explore some of these issues and highlight how we are starting to translate them into clinically relevant tools for lung cancer patients.

Indexed as

Signal TransductionAngiogenesis InhibitorsAnimalsBiomedical ResearchCarcinoma, Non-Small-Cell LungEpigenesis, GeneticErbB ReceptorsGene Expression Regulation, NeoplasticHumansImmunotherapyLung NeoplasmsNeoplastic Stem CellsNeovascularization, PathologicProtein Kinase InhibitorsWnt ProteinsAngiogenesis InhibitorsErbB ReceptorsProtein Kinase InhibitorsWnt Proteins

Identifiers

PMID19763051
PMCPMC3066262
OpenAlexW138860792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.