ArticleAnesthesia and analgesia2009
The electrocortical effects of enflurane: experiment and theory.
Article in Anesthesia and analgesia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Genetic Assessment of Neurotoxicity Accompanied by Inhalational Anesthesia in Preclinical Studies with Focus on Sevoflurane and Isoflurane-A Narrative Review.Brain sciences · 2026Review
- Modeling cortical synaptic effects of anesthesia and their cholinergic reversal.PLoS computational biology · 2022Article
- Contributions of synaptic and astrocyte physiology to the anaesthetised encephalogram revealed using a computational model.British journal of anaesthesia · 2021Article
- Article
- Frontal-temporal functional connectivity of EEG signal by standardized permutation mutual information during anesthesia.Cognitive neurodynamics · 2019Article
- Article
- Repertoire of mesoscopic cortical activity is not reduced during anesthesia.Neuroscience · 2016Article
- Modeling the dynamical effects of anesthesia on brain circuits.Current opinion in neurobiology · 2014Review
- Emergence from general anesthesia and the sleep-manifold.Frontiers in systems neuroscience · 2014Article
- Dynamical changes in neurological diseases and anesthesia.Current opinion in neurobiology · 2012Review
- Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia.Frontiers in integrative neuroscience · 2012Article
- Cross-approximate entropy of cortical local field potentials quantifies effects of anesthesia--a pilot study in rats.BMC neuroscience · 2010Article
- Article
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7 authors.
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Abstract
backgroundHigh concentrations of enflurane will induce a characteristic electroencephalogram pattern consisting of periods of suppression alternating with large short paroxysmal epileptiform discharges (PEDs). In this study, we compared a theoretical computer model of this activity with real local field potential (LFP) data obtained from anesthetized rats.
methodsAfter implantation of a high-density 8 x 8 electrode array in the visual cortex, the patterns of LFP and multiunit spike activity were recorded in rats during 0.5, 1.0, 1.5, and 2.0 minimum alveolar anesthetic concentration (MAC) enflurane anesthesia. These recordings were compared with computer simulations from a mean field model of neocortical dynamics. The neuronal effect of increasing enflurane concentration was simulated by prolonging the decay time constant of the inhibitory postsynaptic potential (IPSP). The amplitude of the excitatory postsynaptic potential (EPSP) was modulated, inverse to the neocortical firing rate.
resultsIn the anesthetized rats, increasing enflurane concentrations consistently caused the appearance of suppression pattern (>1.5 MAC) in the LFP recordings. The mean rate of multiunit spike activity decreased from 2.54/s (0.5 MAC) to 0.19/s (2.0 MAC). At high MAC, the majority of the multiunit action potential events became synchronous with the PED. In the theoretical model, prolongation of the IPSP decay time and activity-dependent EPSP modulation resulted in output that was similar in morphology to that obtained from the experimental data. The propensity for rhythmic seizure-like activity in the model could be determined by analysis of the eigenvalues of the equations.
conclusionIt is possible to use a mean field theory of neocortical dynamics to replicate the PED pattern observed in LFPs in rats under enflurane anesthesia. This pattern requires a combination of a moderately increased total area under the IPSP, prolonged IPSP decay time, and also activity-dependent modulation of EPSP amplitude.
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