ArticleAmerican journal of respiratory and critical care medicine2009
Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice.
Article in American journal of respiratory and critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Prenatal Exposure toEnvironmental health perspectives · 2019Article
- Ozone augments interleukin-8 production induced by ambient particulate matter.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2018Article
- A Framework to Address Challenges in Communicating the Developmental Origins of Health and Disease.Current environmental health reports · 2016Article
- Retraction: Maternal Exposure to Particulate Matter Increases Postnatal Ozone-induced Airway Hyperreactivity in Juvenile Mice.American journal of respiratory and critical care medicine · 2016Article
- Prenatal Particulate Matter/Tobacco Smoke Increases Infants' Respiratory Infections: COCOA Study.Allergy, asthma & immunology research · 2015Article
- Developmental Programming: Priming Disease Susceptibility for Subsequent Generations.Current epidemiology reports · 2015Article
- Evaluating potential response-modifying factors for associations between ozone and health outcomes: a weight-of-evidence approach.Environmental health perspectives · 2014Review
- In utero and early life exposure to diesel exhaust air pollution increases adult susceptibility to heart failure in mice.Particle and fibre toxicology · 2013Article
- Perinatal factors in neonatal and pediatric lung diseases.Expert review of respiratory medicine · 2013Article
- Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice.Environmental health perspectives · 2013Article
- Intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity in neonatal rats.Pediatric research · 2013Article
- Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring.American journal of respiratory cell and molecular biology · 2012Article
- Biochemical effects of ozone on asthma during postnatal development.Biochimica et biophysica acta · 2011Review
- Prenatal exposure to polycyclic aromatic hydrocarbons, environmental tobacco smoke and asthma.Respiratory medicine · 2011Article
- Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Hyaluronan signaling during ozone-induced lung injury requires TLR4, MyD88, and TIRAP.PloS one · 2011Article
- MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- Mast cells mediate hyperoxia-induced airway hyper-reactivity in newborn rats.Pediatric research · 2010Article
- Update in environmental and occupational medicine 2009.American journal of respiratory and critical care medicine · 2010Review
- Early life environment and developmental immunotoxicity in inflammatory dysfunction and disease.Toxicological and environmental chemistryArticle
Corrections and comments
- Retraction · 2016-03-01Investigation by Company/Institution · Unreliable Data ·
- Commented on by
- Retracted
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleEpidemiologic studies implicate air pollutant exposure during pregnancy as a risk factor for wheezing in offspring. Ozone exposure is linked to exacerbations of wheezing in children.
objectivesTo determine if maternal pulmonary exposure to traffic-related particles during pregnancy augments ozone-induced airway hyperresponsiveness in offspring.
methodsC57BL6 time-mated mice were given NIST SRM#1648 (particulate matter [PM]) 0.48 mg, saline vehicle, or no treatment by tracheal insufflation twice weekly for 3 weeks. PM exposure augmented maternal lung inflammation and placental TNF-alpha, Keratinocyte-derived cytokine (KC), and IL-6 (measured at gestation Day 18). After parturition, dams and litters were exposed to air or ozone 1 ppm 3 h/d, every other day, thrice weekly for 4 weeks. Respiratory system resistance in pups was measured at baseline and after administration of nebulized methacholine. MEASUREMENTS AND MAIN
resultsOzone increased airway hyperresponsiveness, but the increase was greatest in pups born to PM-treated dams. Whole-lung TNF-alpha, IL-1beta, KC, IL-6, and MCP-1 were increased in ozone-treated pups, with the greatest increase in pups born to dams given PM. Airway epithelial mucous metaplasia estimated by periodic acid-Schiff Alcian blue staining was increased in ozone-exposed pups born to PM-treated dams. Alveolar development, determined by morphometry, and airway smooth muscle bulk, estimated using alpha-actin histochemistry, were unaffected by prenatal or postnatal treatment.
conclusionsMaternal pulmonary exposure to PM during pregnancy augments placental cytokine expression and postnatal ozone-induced pulmonary inflammatory cytokine responses and ozone-induced airway hyperresponsiveness without altering airway structure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.