ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2010
Caenorhabditis elegans P5B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells.FEBS open bio · 2026Article
- Mechanistic elucidation of a terpenoid nano-bionematicide for the management of root-knot nematodes, Meloidogyne incognita infecting tomato.Scientific reports · 2026Article
- A noncanonical polyamine from bacteria antagonizes host mitochondrial function.Nature communications · 2025Article
- Polyamine homeostasisbioRxiv : the preprint server for biology · 2025Article
- c-MYC-Driven Polyamine Metabolism in Ovarian Cancer: From Pathogenesis to Early Detection and Therapy.Cancers · 2023Review
- Sublethal concentrations of conventional nematicides alter the physiological activities of Meloidogyne incognita and suppress parasitism.Scientific reports · 2023Article
- ATP13A2 (PARK9) and basal ganglia function.Frontiers in neurology · 2023Review
- Structural basis of polyamine transport by human ATP13A2 (PARK9).Molecular cell · 2021Article
- Leaf herbivory counteracts nematode-triggered repression of jasmonate-related defenses in tomato roots.Plant physiology · 2021Article
- Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2.Cell discovery · 2021Article
- ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- The identification of differentially expressed genes between extremes of placental efficiency in maternal line gilts on day 95 of gestation.BMC genomics · 2019Article
- P-type transport ATPases in Leishmania and Trypanosoma.Parasite (Paris, France) · 2019Review
- Overlapping expression patterns and functions of three paralogous P5B ATPases in Caenorhabditis elegans.PloS one · 2018Article
- Article
- Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model Suggests the Existence of Multiple Transport Systems.Medical sciences (Basel, Switzerland) · 2017Article
- Putrescine independent wound response phenotype is produced by ODC-like RNAi in planarians.Scientific reports · 2017Article
- ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers.American journal of cancer research · 2016Article
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8 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Physiological polyamines are required in various biological processes. In the current study, we used norspermidine, a structural analog of the natural polyamine spermidine, to investigate polyamine uptake in the model organism Caenorhabditis elegans. Norspermidine was found to have two remarkable effects: it is toxic for the nematode, without affecting its food, Escherichia coli; and it hampers RNA interference. By characterizing a norspermidine-resistant C. elegans mutant strain that has been isolated in a genetic screen, we demonstrate that both effects, as well as the uptake of a fluorescent polyamine-conjugate, depend on the transporter protein CATP-5, a novel P(5B)-type ATPase. To our knowledge, CATP-5 represents the first P(5)-type ATPase that is associated with the plasma membrane, being expressed in the apical membrane of intestinal cells and the excretory cell. Moreover, genetic interaction studies using C. elegans polyamine synthesis mutants indicate that CATP-5 has a function redundant to polyamine synthesis and link reduced polyamine levels to retarded postembryonic development, reduced brood size, shortened life span, and small body size. We suggest that CATP-5 represents a crucial component of the pharmacologically important polyamine transport system, the molecular nature of which has not been identified so far in metazoa.
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