Evidence map›Paper›PMID 19762543›Full record

ReviewMolecular endocrinology (Baltimore, Md.)2010

Minireview: Nuclear receptor-controlled steroid hormone synthesis and metabolism.

Jinhan He, Qiuqiong Cheng, Wen Xie

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular endocrinology (Baltimore, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jinhan HeCenter for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Qiuqiong Cheng
Wen Xie
University of Pittsburgh · US

Funding

Regulation of Sulfotransferases by LXR and its Implication in PathophysiologyR01ES014626 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, WEN · 2007 to 2011
$1.6M
Phase II UDP-glucuronosyltransferases by PXRR01ES012479 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, WEN · 2003 to 2007
$1.4M
The Hepatoprotective Role of the Orphan Nuclear Receptor LXRR01DK076962 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, WEN · 2009 to 2010
$900k
NIDDK NIH HHS DK076962NIDDK NIH HHS R01 DK076962NIEHS NIH HHS ES012479NIEHS NIH HHS ES014626NIEHS NIH HHS R01 ES012479NIEHS NIH HHS R01 ES014626
6 · The paper itself

Abstract

Steroid hormones are essential in normal physiology whereas disruptions in hormonal homeostasis represent an important etiological factor for many human diseases. Steroid hormones exert most of their functions through the binding and activation of nuclear hormone receptors (NRs or NHRs), a superfamily of DNA-binding and often ligand-dependent transcription factors. In recent years, accumulating evidence has suggested that NRs can also regulate the biosynthesis and metabolism of steroid hormones. This review will focus on the recent progress in our understanding of the regulatory role of NRs in hormonal homeostasis and the implications of this regulation in physiology and diseases.

Indexed as

AnimalsFemaleGonadal Steroid HormonesHomeostasisHumansMaleReceptors, Cytoplasmic and NuclearGonadal Steroid HormonesReceptors, Cytoplasmic and Nuclear

Identifiers

PMID19762543
PMCPMC2803680
OpenAlexW2065157487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.