ArticleJournal of the American Society of Nephrology : JASN2009
Proliferation and migration of label-retaining cells of the kidney papilla.
Article in Journal of the American Society of Nephrology : JASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 96 citations in OpenAlex.
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- Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration.Nature communications · 2022Article
- Determining lineage relationships in kidney development and disease.Nature reviews. Nephrology · 2022Review
- Stem cells: a potential treatment option for kidney diseases.Stem cell research & therapy · 2020Review
- Kidney Cells Regeneration: Dedifferentiation of Tubular Epithelium, Resident Stem Cells and Possible Niches for Renal Progenitors.International journal of molecular sciences · 2019Review
- Three Optimized Methods for In Situ Quantification of Progenitor Cell Proliferation in Embryonic Kidneys Using BrdU, EdU, and PCNA.Canadian journal of kidney health and disease · 2019Article
- Inhibition of mTORC1 signaling protects kidney from irradiation-induced toxicity via accelerating recovery of renal stem-like cells.Stem cell research & therapy · 2018Article
- Kidney-Derived c-KitStem cells translational medicine · 2018Article
- Biomarker discovery for renal cancer stem cells.The journal of pathology. Clinical research · 2018Review
- Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Comparing adult renal stem cell identification, characterization and applications.Journal of biomedical science · 2017Review
- A label-retaining but unipotent cell population resides in biliary compartment of mammalian liver.Scientific reports · 2017Article
- Cellular plasticity in kidney injury and repair.Nature reviews. Nephrology · 2017Review
- A Subpopulation of Label-Retaining Cells of the Kidney Papilla Regenerates Injured Kidney Medullary Tubules.Stem cell reports · 2016Article
- The role of long-term label-retaining cells in the regeneration of adult mouse kidney after ischemia/reperfusion injury.Stem cell research & therapy · 2016Article
- Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice.Cell reports · 2016Article
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9 authors at 2 institutions in 2 countries.
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Abstract
The kidney papilla contains a population of cells with several characteristics of adult stem cells, including the retention of proliferation markers during long chase periods (i.e., they are label-retaining cells [LRCs]). To determine whether the papillary LRCs generate new cells in the normal adult kidney, we examined cell proliferation throughout the kidney and found that the upper papilla is a site of enhanced cell cycling. Using genetically modified mice that conditionally expressed green fluorescence protein fused to histone 2B, we observed that the LRCs of the papilla proliferated only in its upper part, where they associate with "chains" of cycling cells. The papillary LRCs decreased in number with age, suggesting that the cells migrated to the upper papilla before entering the cell cycle. To test this directly, we marked papillary cells with vital dyes in vivo and found that some cells in the kidney papilla, including LRCs, migrated toward other parts of the kidney. Acute kidney injury enhanced both cell migration and proliferation. These results suggest that during normal homeostasis, LRCs of the kidney papilla (or their immediate progeny) migrate to the upper papilla and form a compartment of rapidly proliferating cells, which may play a role in repair after ischemic injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.