ArticleNeuroImage2011
Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates.
Article in NeuroImage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 65 citations in OpenAlex.
- Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma.Neuro-oncology · 2010Trial
- Targeting the IL4 receptor with MDNA55 in patients with recurrent glioblastoma: Results of a phase IIb trial.Neuro-oncology · 2023Article
- Polymer nanocarriers for targeted local delivery of agents in treating brain tumors.Nanotechnology · 2022Review
- Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseases.Molecular neurobiology · 2022Review
- Development of a novel frameless skull-mounted ball-joint guide array for use in image-guided neurosurgery.Journal of neurosurgery · 2020Article
- Trial of magnetic resonance-guided putaminal gene therapy for advanced Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2019Article
- Gene Therapy for Neurodegenerative Diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- Imaging of Convective Drug Delivery in the Nervous System.Neurosurgery clinics of North America · 2017Review
- Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges.NPJ Regenerative medicine · 2017Review
- Accuracy of direct magnetic resonance imaging-guided placement of drug infusion cannulae.Journal of neurosurgery · 2015Article
- The Relation between Catheter Occlusion and Backflow during Intraparenchymal Cerebral Infusions.Stereotactic and functional neurosurgery · 2015Article
- Convection-enhanced drug delivery to the brain: therapeutic potential and neuropathological considerations.Brain pathology (Zurich, Switzerland) · 2014Review
- Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy.Frontiers in neuroanatomy · 2014Article
- Effect of needle insertion speed on tissue injury, stress, and backflow distribution for convection-enhanced delivery in the rat brain.PloS one · 2014Article
- Gene therapy for misfolding protein diseases of the central nervous system.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Review
- Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model.Cancer gene therapy · 2013Article
- Physiology of the intrathecal bolus: the leptomeningeal route for macromolecule and particle delivery to CNS.Molecular pharmaceutics · 2013Review
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- Radially branched deployment for more efficient cell transplantation at the scale of the human brain.Stereotactic and functional neurosurgery · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Optimal results in the direct brain delivery of brain therapeutics such as growth factors or viral vector into primate brain depend on reproducible distribution throughout the target region. In the present study, we retrospectively analyzed MRI of 25 convection-enhanced delivery (CED) infusions with MRI contrast into the putamen of non-human primates (NHP). Infused volume (V(i)) was compared to total volume of distribution (V(d)) versus V(d) within the target putamen. Excellent distribution of contrast agent within the putamen was obtained in eight cases that were used to define an optimal target volume or "green" zone. Partial or poor distribution with leakage into adjacent anatomical structures was noted in 17 cases, defining "blue" and "red" zones, respectively. Quantitative containment (99±1%) of infused gadoteridol within the putamen was obtained when the cannula was placed in the green zone, 87±3% in the blue zone and 49±0.05% in the red zone. These results were used to determine a set of 3D stereotactic coordinates that define an optimal site for putaminal infusions in NHP and human putamen. We conclude that cannula placement and definition of optimal (green zone) stereotactic coordinates have important implications in ensuring effective delivery of therapeutics into the putamen utilizing routine stereotactic MRI localization procedures and should be considered when local therapies such as gene transfer or protein administration are being translated into clinical therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.