ArticleNutritional neuroscience2009
Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice.
Article in Nutritional neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Vitamin C Status and Cognitive Function: A Systematic Review.Nutrients · 2017Pooled it
- Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures.Archives of neurology · 2012Trial
- Intramuscular delivery of recombinant AAV expressing EpoR76E improves memory and is neuroprotective in 5xFAD transgenics.Research square · 2025Article
- Prolactin is an Endogenous Antioxidant Factor in Astrocytes That Limits Oxidative Stress-Induced Astrocytic Cell Death via the STAT3/NRF2 Signaling Pathway.Neurochemical research · 2024Article
- Factors influencing the coping abilities in clinic nursing students under public health emergency (COVID-19): a cross-sectional study.BMC nursing · 2021Article
- Nanonaringenin and Vitamin E Ameliorate Some Behavioral, Biochemical, and Brain Tissue Alterations Induced by Nicotine in Rats.Journal of toxicology · 2021Article
- The Role of Mitochondrial Calcium Homeostasis in Alzheimer's and Related Diseases.International journal of molecular sciences · 2020Review
- Vitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of Alzheimer's disease.Iranian journal of basic medical sciences · 2020Article
- Lentiviral-mediated knock-down of GD3 synthase protects against MPTP-induced motor deficits and neurodegeneration.Neuroscience letters · 2019Article
- Plasma Vitamin C Concentrations and Cognitive Function: A Cross-Sectional Study.Frontiers in aging neuroscience · 2019Article
- Assessment of Improvement in Oxidative Stress Indices with Resocialization in Memory Retrieval in Y-Maze in Male Rats.Journal of experimental neuroscience · 2018Article
- Role of Vitamin E in the Treatment of Alzheimer's Disease: Evidence from Animal Models.International journal of molecular sciences · 2017Review
- Oxidative stress, serotonergic changes and decreased ultrasonic vocalizations in a mouse model of Smith-Lemli-Opitz syndrome.Genes, brain, and behavior · 2017Article
- Oxidative stress signaling to chromatin in health and disease.Epigenomics · 2016Review
- Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer's Disease: Impacts on Cognitive Decline.Nutrients · 2015Review
- Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics.Neurobiology of disease · 2015Article
- Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice.ACS chemical neuroscience · 2015Article
- Targeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunities.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Review
- Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.Genes, brain, and behavior · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The present study investigated the relationships among oxidative stress, beta-amyloid and cognitive abilities in the APP/PSEN1 double-transgenic mouse model of Alzheimer's disease. In two experiments, long-term dietary supplements were given to aged APP/PSEN1 mice containing vitamin C alone (1 g/kg diet; Experiment 1) or in combination with a high (750 IU/kg diet, Experiments 1 and 2) or lower (400 IU/kg diet, Experiment 2) dose of vitamin E. Oxidative stress, measured by F(4)-neuroprostanes or malondialdehyde, was elevated in cortex of control-fed APP/PSEN1 mice and reduced to wild-type levels by vitamin supplementation. High-dose vitamin E with C was less effective at reducing oxidative stress than vitamin C alone or the low vitamin E+C diet combination. The high-dose combination also impaired water maze performance in mice of both genotypes. In Experiment 2, the lower vitamin E+C treatment attenuated spatial memory deficits in APP/PSEN1 mice and improved performance in wild-type mice in the water maze. Amyloid deposition was not reduced by antioxidant supplementation in either experiment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.