ArticleEpilepsia2009
Animal models of focal cortical dysplasia and tuberous sclerosis complex: recent progress toward clinical applications.
Article in Epilepsia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Multimodal age-dependent diffusion-MRI analysis of the neocortex in a rat model of cortical dysplasia.Scientific reports · 2026Article
- The Mechanism Underlying the Abnormal Expression of α-Synuclein in the Cortical Lesions of Patients With FCD Type IIb and TSC.CNS neuroscience & therapeutics · 2026Article
- Metabolic changes in mTOR pathway-associated cortical malformation.Frontiers in neuroscience · 2026Review
- Analysis of cortical dysplasias using b-tensor encoding diffusion MRI in an animal model.PloS one · 2026Article
- The Role of mTOR Signaling in Tumor-Induced Alterations to Neuronal Function in Diffusely Infiltrating Glioma.Biomedicines · 2025Review
- Neurochemical characteristics of pathological tissues in epilepsy: A preliminaryEuropean journal of radiology open · 2025Article
- Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia.Signal transduction and targeted therapy · 2023Article
- Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.Frontiers in neurology · 2023Article
- Multi-tensor diffusion abnormalities of gray matter in an animal model of cortical dysplasia.Frontiers in neurology · 2023Article
- Neuroinflammation: A Signature or a Cause of Epilepsy?International journal of molecular sciences · 2021Review
- Genotoxic Damage During Brain Development Presages Prototypical Neurodegenerative Disease.Frontiers in neuroscience · 2021Review
- New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives.Journal of anatomy · 2019Review
- A New Rat Model of Epileptic Spasms Based on Methylazoxymethanol-Induced Malformations of Cortical Development.Frontiers in neurology · 2017Article
- Rats with Malformations of Cortical Development Exhibit Decreased Length of AIS and Hypersensitivity to Pilocarpine-Induced Status Epilepticus.Neurochemical research · 2016Article
- Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex.Journal of neuroinflammation · 2016Article
- Activation of extracellular regulated kinase and mechanistic target of rapamycin pathway in focal cortical dysplasia.Neuropathology : official journal of the Japanese Society of Neuropathology · 2016Article
- Bayesian network and mechanistic hierarchical structure modeling of increased likelihood of developing intractable childhood epilepsy from the combined effect of mtDNA variants, oxidative damage, and copy number.Journal of molecular neuroscience : MN · 2014Article
- Past and present definitions of epileptogenesis and its biomarkers.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Review
- Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia.Cerebral cortex (New York, N.Y. : 1991) · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Focal cortical dysplasia (FCD) and related malformations of cortical development (MCDs) represent an increasingly recognized cause of medically intractable epilepsy. However, the underlying mechanisms of epileptogenesis are poorly understood, and treatments for epilepsy due to various cortical malformations are often limited or ineffective. Animal models offer a number of advantages for investigating cellular and molecular mechanisms of epileptogenesis and developing novel, rational therapies for MCD-related epilepsy. This review highlights specific examples of how animal models have been useful in addressing several clinically relevant issues about epilepsy due to FCDs and related cortical malformations, including the pathologic and clinical features, etiologic factors, localization of the epileptogenic zone, neuronal and astrocytic contributions to epileptogenesis, and the development of antiepileptogenic therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.