ReviewPharmacogenomics2009
Genetic polymorphisms associated with acute lung injury.
Review in Pharmacogenomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Mitochondrial function in lungs of rats with different susceptibilities to hyperoxia-induced acute lung injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Component 1 Inhibitor Missense (Val480Met) Variant Is Associated With Gene Expression and Sepsis Development in Neonatal Lung Disease.Frontiers in pediatrics · 2022Article
- Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness.Shock (Augusta, Ga.) · 2020Review
- Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critically [corrected] ill patients?Annals of intensive care · 2017Review
- Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.American journal of respiratory and critical care medicine · 2017Article
- Genetic and epigenetic factors in the regulation of the immune response.Current opinion in pediatrics · 2016Review
- Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-κB pathway.Cell cycle (Georgetown, Tex.) · 2015Article
- Haplotype analysis of ApoAI gene and sepsis-associated acute lung injury.Lipids in health and disease · 2014Article
- Review
- Association of apolipoprotein A1 -75 G/A polymorphism with susceptibility to the development of acute lung injury after cardiopulmonary bypass surgery.Lipids in health and disease · 2013Article
- Functional genomic assessment of phosgene-induced acute lung injury in mice.American journal of respiratory cell and molecular biology · 2013Article
- Gene-environment interactions in cardiovascular disease.European journal of cardiovascular nursing · 2012Review
- Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury.Frontiers in bioscience (Landmark edition) · 2012Review
- Life or death? A physiogenomic approach to understand individual variation in responses to hemorrhagic shock.Current genomics · 2011Article
- Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.American journal of respiratory and critical care medicine · 2011Article
- Integrating microRNAs into a system biology approach to acute lung injury.Translational research : the journal of laboratory and clinical medicine · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Acute lung injury and acute respiratory distress syndrome are the result of intense inflammation in the lungs leading to respiratory failure. The causes of acute lung injury/acute respiratory distress syndrome are numerous (e.g., pneumonia, sepsis and trauma) but the reasons why certain individuals develop lung injury in response to these stimuli and others do not are not well understood. There is ample evidence in the literature that gene-host and gene-environment interactions may play a large role in the morbidity and mortality associated with this syndrome. In this review, we initially discuss methods for identification of candidate acute lung injury/acute respiratory distress syndrome susceptibility genes using a number of model systems including in vitro cell systems and inbred mice. We then describe examples of polymorphisms in genes that have been associated with the pathogenesis of acute lung injury/acute respiratory distress syndrome in human case-control studies. Systematic bench to bedside approaches to understand the genetic contribution to acute lung injury/acute respiratory distress syndrome have provided important insight to this complex disease and continuation of these investigations could lead to the development of novel prevention or intervention strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.