ArticleInflammatory bowel diseases2010
Incidence of stricturing and penetrating complications of Crohn's disease diagnosed in pediatric patients.
Article in Inflammatory bowel diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 81 citations in OpenAlex.
- Efficacy of Adalimumab for Treatment of Perianal Fistula in Children with Moderately to Severely Active Crohn's Disease: Results from IMAgINE 1 and IMAgINE 2.Journal of Crohn's & colitis · 2018Trial
- The prognostic role of magnetic resonance enterography at diagnosis in paediatric isolated ileocaecal Crohn's disease.Journal of pediatric gastroenterology and nutrition · 2026Article
- Expect the unexpected: A case of penetrating Crohn's disease complicated by foreign body ingestion.JPGN reports · 2026Article
- Nutritional Approach in Pediatric Patients with Inflammatory Bowel Disease: Treatment, Risk and Challenges.Nutrients · 2025Review
- Hyperbaric Oxygen Therapy in the Management of Refractory Perianal Crohn's Disease.Journal of clinical medicine · 2025Article
- Review
- Noninvasive Stool RNA Test Approximates Disease Activity in Patients With Crohn's Disease.Gastro hep advances · 2024Article
- Early Anti-Tumor-Necrosis-Factor Therapy for Crohn's Disease-Related Abdominal Abscesses and Phlegmon in Children.Digestive diseases and sciences · 2023Article
- What Are the Different Phenotypes of Inflammatory Bowel Disease in Asia?Gut and liver · 2022Review
- Surgical Planning in Penetrating Abdominal Crohn's Disease.Frontiers in surgery · 2022Review
- Perianal disease onset age is associated with distinct disease features and need for intestinal resection in perianal Crohn's disease: a ten-year hospital-based observational study in China.BMC gastroenterology · 2021Observational
- Can Conventional and Diffusion-Weighted MR Enterography Biomarkers Differentiate Inflammatory from Fibrotic Strictures in Crohn's Disease?Medicina (Kaunas, Lithuania) · 2021Article
- Association Between Steroid-Sparing Therapy and the Risk of Perianal Fistulizing Complications Among Young Patients With Crohn Disease.JAMA network open · 2020Article
- Identifying perianal fistula complications in pediatric patients with Crohn's disease using administrative claims.PloS one · 2019Article
- Magnetic resonance enterography findings of a gastrocolic fistula in Crohn's disease.Quantitative imaging in medicine and surgery · 2016Article
- Current tecniques and new perpectives research of magnetic resonance enterography in pediatric Crohn's disease.World journal of radiology · 2016Review
- MR enterography-histology comparison in resected pediatric small bowel Crohn disease strictures: can imaging predict fibrosis?Pediatric radiology · 2016Article
- Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis.Inflammatory bowel diseases · 2015Article
- Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Inflammatory bowel disease in pediatric and adolescent patients: a biomolecular and histopathological review.World journal of gastroenterology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundThe development of disease complications is poorly characterized in pediatric patients with Crohn's disease (CD).
methodsWe retrospectively determined the cumulative incidence of stricturing and penetrating complications of CD prior to first surgery utilizing data from 989 consecutively enrolled CD patients (age 0-17 years at diagnosis) collected between January 2000 and November 2003 and stored in the Pediatric IBD Consortium Registry.
resultsMean age at diagnosis was 11.5 +/- 3.8 (standard deviation) years. Median follow-up time was 2.8 years. Prior to first surgery, the cumulative incidence of stricturing or penetrating complications was 27% at 5 years and 38% at 10 years from the diagnosis of inflammatory bowel disease. The cumulative incidence of complicated disease was lowest in isolated colonic disease (P = 0.009). Penetrating complications that followed stricturing complications prior to first surgery occurred within 2 years of stricturing complications (cumulative incidence was 13% at 2 years from diagnosis of stricturing disease). Stricturing complications that followed penetrating complications prior to first surgery occurred within 8 years of penetrating complications (cumulative incidence was 26% at 8 years from diagnosis of penetrating complications).
conclusionsStrictures, abscesses, and fistulas are common in pediatric CD. Earlier aggressive management may be indicated. Prospective study is required to identify genetic and serologic markers that predict a patient's risk for the development of complicated disease and to determine optimal treatment regimens.
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