ArticleClinical orthopaedics and related research2009
Are endogenous BMPs necessary for bone healing during distraction osteogenesis?
Article in Clinical orthopaedics and related research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- TP508 Promotes Bone Regeneration on Distraction OsteogenesisCurrent pharmaceutical biotechnology · 2025Article
- Mechanical Characterization at the Microscale of Mineralized Bone Callus after Bone Lengthening.Materials (Basel, Switzerland) · 2022Article
- Assessment of the effect of systemic delivery of sclerostin antibodies on Wnt signaling in distraction osteogenesis.Journal of bone and mineral metabolism · 2018Article
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- Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Comprehensive Review of Adipose Stem Cells and Their Implication in Distraction Osteogenesis and Bone Regeneration.BioMed research international · 2015Review
- The effect of altering the mechanical loading environment on the expression of bone regenerating molecules in cases of distraction osteogenesis.Frontiers in endocrinology · 2014Review
- Effects of caffeic acid phenethyl ester and melatonin on distraction osteogenesis: an experimental study.SpringerPlus · 2014Article
- The effect of heparan sulfate application on bone formation during distraction osteogenesis.PloS one · 2013Article
- Spatial and temporal localization of WNT signaling proteins in a mouse model of distraction osteogenesis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healing.Bone · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous reports suggest the application of exogenous BMPs can accelerate bone formation during distraction osteogenesis (DO). However, there are drawbacks associated with the use of exogenous BMPs. A possible alternative to the use of exogenous BMPs is to upregulate the expression of endogenous BMPs. Since DO results in spontaneously generated de novo bone formation in a uniform radiographic, histological, and biomechanical temporal sequence, a genetically engineered model lacking endogenous BMP2 should have measurable deficits in bone formation at different time points. We performed DO on BMP2(fl/+) and BMP2(fl/+ cre) mice using a miniature Ilizarov fixator. Distracted samples were collected at various time points and analyzed using real time-quantitative PCR, lCT, radiology, immunohistochemistry, histology, and biomechanical testing. Immunohistochemical studies of 34-day heterozygous samples showed reduced expression of BMP2, BMP7, BMPR1a, ACTR1, and ACTR2b. lCT analysis of 51-day heterozygous samples revealed a decrease in trabecular number and increase in trabecular separation. Biomechanical testing of 51-day heterozygous samples revealed decreased stiffness and increased ultimate displacement. Radiological analysis showed the heterozygotes contained a decreased bone fill score at 17, 34, and 51 days. These data suggest endogenous BMPs are important for bone healing and manipulating endogenous BMPs may help accelerate bone consolidation during DO.
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Registered trials
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