ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2010
The molecular pathogenesis of Barrett's esophagus: common signaling pathways in embryogenesis metaplasia and neoplasia.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Genetic Mouse Models and Induced Pluripotent Stem Cells for Studying Tracheal-Esophageal Separation and Esophageal Development.Stem cells and development · 2020Article
- Analysis of salivary microRNA expression profiles and identification of novel biomarkers in esophageal cancer.Oncology letters · 2017Article
- Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan.Cell host & microbe · 2016Article
- Dpp signaling determines regional stem cell identity in the regenerating adult Drosophila gastrointestinal tract.Cell reports · 2013Article
- Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development.World journal of gastroenterology · 2013Review
- Diagnosis and management of Barrett's esophagus.The Surgical clinics of North America · 2012Review
- Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression.Cancer science · 2012Article
- Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling.PloS one · 2012Article
- Importance of a multidisciplinary approach for the treatment of Barrett's esophagus.Updates in surgery · 2011Review
- Gastroesophageal reflux disease: From pathophysiology to treatment.World journal of gastroenterology · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Barrett's esophagus has been recognized for over 50 years, the cellular and molecular mechanisms leading to the replacement of squamous esophageal epithelium with a columnar type are largely unknown. Barrett's is known to be an acquired process secondary to chronic gastroesophageal reflux disease and occurs in the presence of severe disruption of the gastroesophageal barrier and reflux of a mixture of gastric and duodenal content. Current hypothesis suggest that epithelial change occurs due to stimulation of esophageal stem cells present in the basal layers of the epithelium or submucosal glands, toward a columnar epithelial differentiation pathway. The transcription factor CDX2 seems to play a key role in promoting the cellular biology necessary for columnar differentiation, and can be induced by bile salt and acid stimulation. Several cellular signaling pathways responsible for modulation of intestinal differentiation have also been identified and include WNT, Notch, BMP, Sonic HH and TGFB. These also have been shown to respond to stimulation by bile acids, acid or both and may influence CDX2 expression. Their relative activity within the stem cell population is almost certainly responsible for the development of the esophageal columnar epithelial phenotype we know as Barrett's esophagus.
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Registered trials
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