ReviewPflugers Archiv : European journal of physiology2010
The role of mitochondrial uncoupling proteins in lifespan.
Review in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Molecular Basis of Cardiomyopathies in Type 2 Diabetes.International journal of molecular sciences · 2024Review
- The role of mitochondrial uncoupling in the regulation of mitostasis after traumatic brain injury.Neurochemistry international · 2024Article
- Immunocytochemical Analysis of Crocin against Oxidative Stress in Trigeminal Sensory Neurons Innervating the Cornea.Molecules (Basel, Switzerland) · 2024Article
- Mitochondrial Metabolism and EV Cargo of Endothelial Cells Is Affected in Presence of EVs Derived from MSCs on Which HIF Is Activated.International journal of molecular sciences · 2023Article
- Review
- Energy Metabolism in the Inner Retina in Health and Glaucoma.International journal of molecular sciences · 2021Review
- Effect of exopolysaccharides from cariogenic bacteria on human gingival fibroblasts.International journal of medical sciences · 2021Article
- Decreased uncoupling protein 2 expression in aging retinal pigment epithelial cells.International journal of ophthalmology · 2019Article
- Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat.Cell death & disease · 2017Article
- Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults.PloS one · 2017Article
- Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection.Journal of bioenergetics and biomembranes · 2015Review
- Oxidative Damage Does Not Occur in Striped Hamsters Raising Natural and Experimentally Increased Litter Size.PloS one · 2015Article
- PI3K/Akt/uncoupling protein 2 signaling pathway may be involved in cell senescence and apoptosis induced by angiotensin II in human vascular endothelial cells.Molecular biology reports · 2014Article
- Minireview: Central Sirt1 regulates energy balance via the melanocortin system and alternate pathways.Molecular endocrinology (Baltimore, Md.) · 2014Review
- TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway.American journal of physiology. Renal physiology · 2013Article
- Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease.Translational neurodegeneration · 2012Article
- Mitochondrial roles and cytoprotection in chronic liver injury.Biochemistry research international · 2012Article
- Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae.Sub-cellular biochemistry · 2012Review
- Intrinsic aerobic capacity sets a divide for aging and longevity.Circulation research · 2011Article
- Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain.Molecular biology of the cell · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The increased longevity in modern societies raised the attention to biological interventions that could promote a healthy aging. Mitochondria are main organelles involved in the production of adenosine triphosphate (ATP), the energetic substrate for cellular biochemical reactions. The production of ATP occurs through the oxidative phosphorylation of intermediate substrates derived from the breakdown of lipids, sugars, and proteins. This process is coupled to production of oxygen reactive species (ROS) that in excess will have a deleterious role in cellular function. The damage promoted by ROS has been emphasized as one of the main processes involved in senescence. In the last decades, the discovery of specialized proteins in the mitochondrial inner membrane that promote the uncoupling of proton flux (named uncoupling proteins-UCPs) from the ATP synthase shed light on possible mechanisms implicated in the buffering of ROS and consequently in the process of aging. UCPs are responsible for a physiological uncoupling that leads to decrease in ROS production inside the mitochondria. Thus, induction of uncoupling through UCPs could decrease the cellular damage that occurs during aging due to excess of ROS. This review will focus on the evidence supporting these mechanisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.