ArticlePsychopharmacology2009
Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Bupropion increases activation in nucleus accumbens during anticipation of monetary reward.Psychopharmacology · 2019Trial
- Does Extended Pre Quit Bupropion Aid in Extinguishing Smoking Behavior?Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Trial
- Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri.Psychopharmacology · 2023Review
- Investigating sex differences and the effect of drug exposure order in the sensory reward-enhancing effects of nicotine and d-amphetamine alone and in combination.Neuropharmacology · 2022Article
- Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects.Psychopharmacology · 2021Article
- Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure.Scientific reports · 2020Article
- A behavioral economic analysis of the value-enhancing effects of nicotine and varenicline and the role of nicotinic acetylcholine receptors in male and female rats.Behavioural pharmacology · 2018Article
- Article
- Nicotine Acutely Enhances Reinforcement from Non-Drug Rewards in Humans.Frontiers in psychiatry · 2017Review
- Sex differences and the role of dopamine receptors in the reward-enhancing effects of nicotine and bupropion.Psychopharmacology · 2017Article
- Nicotine self-administration research: the legacy of Steven R. Goldberg and implications for regulation, health policy, and research.Psychopharmacology · 2016Review
- Behavioral mechanisms underlying nicotine reinforcement.Current topics in behavioral neurosciences · 2015Review
- Sensory reinforcement-enhancing effects of nicotine via smoking.Experimental and clinical psychopharmacology · 2014Article
- Quantifying nicotine's value-enhancement effect using a behavioral economic approach.Journal of the experimental analysis of behavior · 2014Article
- Possible reinforcement enhancing effects of bupropion during initial smoking abstinence.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Article
- Adolescent exposure to nicotine results in reinforcement enhancement but does not affect adult responding in rats.Drug and alcohol dependence · 2012Article
- Nicotine self-administered directly into the VTA by rats is weakly reinforcing but has strong reinforcement enhancing properties.Psychopharmacology · 2012Article
- The role of conditioning history and reinforcer strength in the reinforcement enhancing effects of nicotine in rats.Psychopharmacology · 2012Article
- Mechanistic insights into nicotine withdrawal.Biochemical pharmacology · 2011Review
- The reinforcement-enhancing effects of nicotine: implications for the relationship between smoking, eating and weight.Physiology & behavior · 2011Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleNicotine serves as a primary reinforcer but also potently enhances responding for nonnicotine stimuli with reinforcing properties. One of the most successful pharmacotherapies for smoking cessation, bupropion, also increases responding for nondrug reinforcers such as food and brain stimulation rewards.
objectiveThe present studies investigated whether treatment with bupropion and nicotine had similar effects on responding for a reinforcing visual stimulus (VS). They also investigated whether the effects of bupropion and nicotine depended on common pharmacological substrates.
resultsNicotine (0.4 mg/kg base) enhanced responding for the VS, and this enhancing effect increased across testing sessions, replicating our previous findings. Bupropion (3, 10, and 30 mg/kg salt) dose-dependently increased responding for the VS. Treatment with 10 and 30 mg/kg bupropion resulted in a profile similar to nicotine; operant responding increased over repeated drug treatments. The reinforcement enhancing effect of nicotine, but not bupropion, was blocked by pretreatment with the nicotinic acetylcholine receptor antagonist mecamylamine. In contrast, the reinforcement enhancing effect of bupropion, but not nicotine, was blocked by pretreatment with the alpha noradrenergic antagonist prazosin.
conclusionThe reinforcement enhancing effects of nicotine and bupropion increased over time and repeated treatments suggesting a shared mechanism of action. However, the reinforcement enhancing effects of nicotine are mediated by nicotinic acetylcholine receptors, whereas the reinforcement enhancing effects of bupropion were mediated by alpha noradrenergic receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.