ArticlePlanta2009
Induction of serotonin biosynthesis is uncoupled from the coordinated induction of tryptophan biosynthesis in pepper fruits (Capsicum annuum) upon pathogen infection.
Article in Planta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Analysis of biosynthetic genes of phenolamides inFrontiers in plant science · 2026Article
- On the Biosynthesis of Bioactive Tryptamines in Black Cohosh (Plants (Basel, Switzerland) · 2025Article
- Metabolic pathway genes for editing to enhance multiple disease resistance in plants.Journal of plant research · 2022Article
- Functional characterization of a catalytically promiscuous tryptophan decarboxylase from camptothecin-producingFrontiers in plant science · 2022Article
- Indolamine accumulation andFrontiers in plant science · 2022Article
- Melatonin in business with abiotic stresses in plants.Physiology and molecular biology of plants : an international journal of functional plant biology · 2020Review
- PaACL silencing accelerates flower senescence and changes the proteome to maintain metabolic homeostasis in Petunia hybrida.Journal of experimental botany · 2020Article
- Untargeted and Targeted Metabolomics and Tryptophan Decarboxylase In Vivo Characterization Provide Novel Insight on the Development of Kiwifruits (International journal of molecular sciences · 2019Article
- The Role of Phyto-Melatonin and Related Metabolites in Response to Stress.Molecules (Basel, Switzerland) · 2018Review
- A Connection between Lysine and Serotonin Metabolism in Rice Endosperm.Plant physiology · 2018Article
- Experimental Evidence and In Silico Identification of Tryptophan Decarboxylase in Citrus Genus.Molecules (Basel, Switzerland) · 2017Article
- Structural Basis of the Substrate Specificity and Enzyme Catalysis of aFrontiers in molecular biosciences · 2017Article
- Aniline is an inducer, and not a precursor, for indole derivatives in Rubrivivax benzoatilyticus JA2.PloS one · 2014Article
- A genome scale metabolic network for rice and accompanying analysis of tryptophan, auxin and serotonin biosynthesis regulation under biotic stress.Rice (New York, N.Y.) · 2013Article
- Biochemical evaluation of the decarboxylation and decarboxylation-deamination activities of plant aromatic amino acid decarboxylases.The Journal of biological chemistry · 2013Article
- Tryptophan decarboxylase plays an important role in ajmalicine biosynthesis in Rauvolfia verticillata.Planta · 2012Article
- Gene identification in black cohosh (Actaea racemosa L.): expressed sequence tag profiling and genetic screening yields candidate genes for production of bioactive secondary metabolites.Plant cell reports · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that serotonin biosynthesis is regulated by tryptophan decarboxylase (TDC) in plants. To determine if TDC plays a rate-limiting role in serotonin biosynthesis, two TDC genes, PepTDC1 and PepTDC2, were cloned from pepper (Capsicum annuum L.) fruits infected with anthracnose fungus and their expression was then examined in various organs, including fruit that had been treated with the fungus or various chemicals. PepTDC1 expression was highly induced in pepper fruits after treatment with fungus and ethylene, while PepTDC2 was constitutively expressed at low levels in all pepper tissues. Additionally, predominant induction of PepTDC1 mRNA and TDC enzyme activity was detected in the unripe-green fruit, but not in the ripe-red fruit upon pathogen infection. Higher expression of TDC in unripe-green fruit was closely associated with increased levels of tryptamine, serotonin, and serotonin derivatives. However, unlike the enhanced serotonin synthesis, tryptophan levels responded unchanged when challenged with the pathogen in both the unripe-green fruit and the ripe-red fruit. Expression of two key tryptophan biosynthetic genes, anthranilate synthase (ASalpha) and tryptophan synthase (TSbeta), remained unchanged in response to treatment. Also, anthranilate synthase enzyme activity remained steady regardless of pathogen infection. Taken together, these results suggest that the synthesis of serotonin was regulated by the induction of TDC without a simultaneous increase in tryptophan levels in pepper fruits.
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