ArticleCytotechnology2009
Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells.
Article in Cytotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 83 citations in OpenAlex.
- Structure and evolution of alanine/serine decarboxylases and the engineering of theanine production.eLife · 2024Article
- L-Theanine and Immunity: A Review.Molecules (Basel, Switzerland) · 2023Review
- An L-theanine derivative targets against SARS-CoV-2 and its Delta and Omicron variants.Heliyon · 2022Article
- L-Theanine inhibits melanoma cell growth and migration via regulating expression of the clock gene BMAL1.European journal of nutrition · 2022Article
- Characterization of L-theanine in tea extracts and synthetic products using stable isotope ratio analysis.Journal of food and drug analysis · 2021Article
- Bacterial Gamma-Glutamyl Transpeptidase, an Emerging Biocatalyst: Insights Into Structure-Function Relationship and Its Biotechnological Applications.Frontiers in microbiology · 2021Review
- Article
- Development of a highly efficient and specific L-theanine synthase.Applied microbiology and biotechnology · 2020Article
- Time-series transcriptomic analysis reveals novel gene modules that control theanine biosynthesis in tea plant (Camellia sinensis).PloS one · 2020Article
- Fabrication of poly(D, L-lactic acid) nanoparticles as delivery system for sustained release of L-theanine.IET nanobiotechnology · 2019Article
- Identification of a Novel Gene Encoding the Specialized Alanine Decarboxylase in Tea (Molecules (Basel, Switzerland) · 2019Article
- L-Theanine Content and Related Gene Expression: Novel Insights into Theanine Biosynthesis and Hydrolysis among Different Tea Plant (Frontiers in plant science · 2017Article
- Suppression of proliferation and migration in highly-metastatic lung cancer cells as well as tumor growth by a new synthesized compound TBrC and its molecular mechanisms of action.Cytotechnology · 2014Article
- Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives.Oncotarget · 2014Article
- Physiological effects of L-theanine on Drosophila melanogaster.Molecules (Basel, Switzerland) · 2013Article
- Article
- Norcantharidin, derivative of cantharidin, for cancer stem cells.Evidence-based complementary and alternative medicine : eCAM · 2013Review
- Induction of apoptosis with mitochondrial membrane depolarization by a glycyrrhetinic acid derivative in human leukemia K562 cells.Cytotechnology · 2012Article
- Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action.Cytotechnology · 2010Article
- Inhibitory effects of norcantharidin against human lung cancer cell growth and migration.Cytotechnology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to investigate the effects of theanine, a tea characteristic amino acid, on human lung cancer and leukemia cells. In the present study, we have demonstrated that theanine suppressed the in vitro and ex vivo growth of human non-small cell lung cancer A549 and leukemia K562 cell lines in dose- and time-dependant manners. In addition, theanine displayed the inhibitory effect on the migration of A549 cells. More importantly, theanine enhanced the anticancer activity of anticancer agents such as trichostatin A (the histone deacetylase inhibitor), berbamine and norcantharidin (the anticancer drugs in China) by strongly reducing the viability and/or migration rate in A549 cells. In addition, theanine significantly suppressed A549 cell invasion. Suppression of A549 cell migration may be one of the important mechanisms of action of theanine against the A549 cell invasion. Our present results suggest that theanine may have the wide therapeutic and/or adjuvant therapeutic application in the treatment of human lung cancer and leukemia.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.