ArticleMolecular biology reports2010
Two novel cSNPs of weaver gene in Chinese indigenous goat and their associations with milk yield.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection.PloS one · 2021Article
- SNP Discovery from Transcriptome of Cashmere Goat Skin.Asian-Australasian journal of animal sciences · 2015Article
- Novel SNPs in the PRDM16 gene and their associations with performance traits in chickens.Molecular biology reports · 2012Article
- Polymorphism of the prion protein gene (PRNP) in two Chinese indigenous cattle breeds.Molecular biology reports · 2011Article
- The CSN1S1 N and F alleles identified by PCR-SSCP and their associations with milk yield and composition in Chinese dairy goats.Molecular biology reports · 2011Article
- Effects of genetic variability of the dairy goat growth hormone releasing hormone receptor (GHRHR) gene on growth traits.Molecular biology reports · 2011Article
- Characterization of the GHR gene genetic variation in Chinese indigenous goat breeds.Molecular biology reports · 2011Article
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10 authors.
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Abstract
Weaver gene plays an essential physiological role in the function of many organs, including brain, heart, kidney and endocrine cells, and also in the regulation of insulin secretion by glucose and/or neurotransmitters. Thus, weaver gene is an important potential candidate gene effecting on performance traits. The objective of this study was to detect the genetic variation of five loci within weaver gene by PCR-SSCP, DNA sequencing and forced PCR-RFLP methods in 1,019 Chinese indigenous goats. Two novel coding SNPs (XM_598993:m.864G>A; XM_598993:m.1224T>A) locating on P3 and P4 loci were identified and detected by MluI and AsuII forced PCR-RFLP, respectively. In the MluI analysis, the frequencies of goat MluI-A allele in the analyzed populations were 0.226, 0.248, 0.096 and 0.088 for XNSN, GZ, SBWC and XJWC, respectively. Genotypic frequencies were found to be significantly different in four breeds (chi2 = 75.842, df = 6, P < 0.001); In the AsuII analysis, the frequencies of goat AsuII-A allele in the analyzed populations were 0.584, 0.441, 0.073 and 0.063 for XNSN, GZ, SBWC and XJWC, respectively. Genotypic frequencies were found to be significantly different among four breeds (chi2 = 399.464, df = 6, P < 0.001). The frequencies of allele MluI-A and AsuII-A in XNSN and GZ populations were significantly higher than those of SBWC and XJWC goats. Association analysis with adjusted milk yield in the XNSN breed indicated that the animals with AsuII-AA genotype owned significantly higher adjusted milk yield than the ones with AsuII-TT genotype in the second lactation (P < 0.05). The observation suggested that the allele "AsuII-A" had the positive effects on adjusted milk yield in the second lactation.
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