ArticleInternational urogynecology journal2010
Decreased nanobacteria levels and symptoms of nanobacteria-associated interstitial cystitis/painful bladder syndrome after tetracycline treatment.
Article in International urogynecology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- The microbiome of interstitial cystitis revealed by 2bRAD-M.Scientific reports · 2026Article
- Exploring the anti-inflammatory effects of phytochemicals in attenuating interstitial cystitis-a literature review.Frontiers in pharmacology · 2025Review
- Preliminary study of the role of nanobacteria in the formation of renal stones in experimental rats and its mechanism.Archives of medical sciences. Atherosclerotic diseases · 2024Article
- Urinary Microbiome in Bladder Diseases-Review.Biomedicines · 2023Review
- Pain in Women: A Perspective Review on a Relevant Clinical Issue that Deserves Prioritization.Pain and therapy · 2021Review
- A new look at the etiology of interstitial cystitis/bladder pain syndrome: extraordinary cultivations.International urology and nephrology · 2019Article
- Molecular pathogenesis of interstitial cystitis/bladder pain syndrome based on gene expression.Journal of cellular physiology · 2019Review
- Interstitial cystitis intravesical therapy.Translational andrology and urology · 2017Review
- Melatonin improves bladder symptoms and may ameliorate bladder damage via increasing HO-1 in rats.Inflammation · 2013Article
- Alterations of microbiota in urine from women with interstitial cystitis.BMC microbiology · 2012Article
- Association between calcifying nanoparticles and placental calcification.International journal of nanomedicine · 2012Article
- The role of calcifying nanoparticles in biology and medicine.International journal of nanomedicine · 2012Review
- Detection of nanobacteria in patients with chronic prostatitis and vaginitis by reverse transcriptase polymerase chain reaction.Korean journal of urology · 2011Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisThis study was designed to detect whether nanobacteria (NB) reside in urine and bladder tissue samples of patients with interstitial cystitis/painful bladder syndrome (IC/PBS) and whether antibiotic therapy targeting these organisms is effective in reducing NB levels and IC/PBS symptoms.
methodsTwenty-seven IC/PBS patients underwent cystoscopy. Bladder biopsies and urine samples were obtained and cultured for NB, which were identified by indirect immunofluorescent staining and transmission electron microscopy.
resultsEleven bladder samples showed growth of microbes that were identified to be similar to NB. Homologous study of the 16S ribosomal RNA gene suggested that the NB could be the pathogen. For enrolled 11 patients, NB levels decreased dramatically after tetracycline treatment, and they reported significant reduction in the severity of IC/PBS symptoms.
conclusionsA high prevalence of NB was observed in female IC/PBS, and anti-NB treatment effectively improved the symptoms, which suggest that NB may cause some cases of IC/PBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.