ReviewImmunologic research2010
Fine-tuning immune surveillance by fever-range thermal stress.
Review in Immunologic research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Long-term health effects of antipyretic drug use in the aging population: a systematic review.Journal of medicine and life · 2024Pooled it
- A new type of biomarker for heat stress: insights from immunology.Frontiers in immunology · 2026Review
- Association between Acute and Chronic Inflammatory States: A Case-Control Study.Homeopathy : the journal of the Faculty of Homeopathy · 2024Article
- Fever temperatures impair hemolysis caused by strains ofHeliyon · 2022Article
- Long-term health effects of antipyretic drug use in the ageing population: protocol for a systematic review.F1000Research · 2020Article
- Febrile temperatures increase in vitro antibody affinity for malarial and dengue antigens.PLoS neglected tropical diseases · 2019Article
- The Genetic Architecture of Early Body Temperature and Its Correlation WithFrontiers in genetics · 2019Article
- Immunology, Immunotherapy, and Translating Basic Science into the Clinic for Bladder Cancer.Bladder cancer (Amsterdam, Netherlands) · 2018Article
- The Impact of Hyperthermia on Receptor-Mediated Interleukin-6 Regulation in Mouse Skeletal Muscle.PloS one · 2016Article
- Measuring soluble ICAM-1 in African populations.PloS one · 2014Article
- Fever in Cancer Treatment: Coley's Therapy and Epidemiologic Observations.Global advances in health and medicine · 2012Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
An effectively orchestrated immune response to infection and disease depends on efficient trafficking of lymphocytes across vascular beds at distinct tissue sites. Local inflammation and systemic fever increase immune surveillance to immune-relevant sites throughout the body. During the initiation phase of inflammation, this tightly regulated process improves leukocyte trafficking to the secondary lymphoid organs where they undergo activation and expansion in response to cognate antigen. In the resolution phase following the clearance of the invading pathogen, lymphocyte entry is rapidly returned to baseline conditions. Specialized blood vessels termed high endothelial venules (HEVs) have emerged as critical 'hotspots' controlling the rate of lymphocyte entry into lymphoid organs during both phases of inflammation. In this review, we will examine the remarkably tight regulation of lymphocyte trafficking across HEVs conferred by inflammatory cues associated with the thermal element of fever. These studies have revealed a novel role for interleukin-6 (IL-6) trans-signaling in eliciting systemic effects on lymphocyte trafficking patterns to fine-tune immune surveillance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.