ArticleClinics (Sao Paulo, Brazil)2009
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress.
Article in Clinics (Sao Paulo, Brazil), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Sertraline as an Antidepressant and Inflammatory Cytokines in Depressive Disorders: A Systematic Review and Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.Frontiers in immunology · 2026Pooled it
- Does creatine affect lipid profile? a systematic review and meta-analysis of randomized placebo-controlled trials.Frontiers in nutrition · 2026Pooled it
- Anti-hypertensive drugs have different effects on ventricular hypertrophy regression.Clinics (Sao Paulo, Brazil) · 2010Pooled it
- Effects of Qi-Fu-Yin on aging of APP/PS1 transgenic mice by regulating the intestinal microbiome.Frontiers in cellular and infection microbiology · 2022Article
- Unraveling the Mystery of Cold Stress-Induced Myocardial Injury.Frontiers in physiology · 2020Review
- Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT.Journal of lipid research · 2015Article
- A review on animal models for screening potential anti-stress agents.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2011Review
- Memantine effects on liver and adrenal gland of rats exposed to cold stress.International archives of medicine · 2011Article
- Sudden cardiac death athletes: a systematic review.Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT · 2010Article
- Electric countershock and cold stress effects on liver and adrenal gland.Clinics (Sao Paulo, Brazil) · 2010Article
- Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats.International archives of medicine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMemantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress.
methodWe used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of -8 degrees C on the last day of the study.
resultsThe MEM group had the largest cardiomyocyte nuclear size (151 +/- 3.5 microm(3) vs. CON: 142 +/- 2.3 microm(3); p<0.05), while the IH group had the smallest mean value of nuclear size. The nuclear size of the IHM group was preserved (125 +/- 2.9 microm(3)) compared to the IH group (108 +/- 1.7 microm(3); p<0.05).
conclusionMemantine prevented the nuclear size reduction of cardiomyocytes in rats exposed to cold stress.
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Registered trials
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