ArticleJournal of oncology2010
Tumor spreading to the contralateral ovary in bilateral ovarian carcinoma is a late event in clonal evolution.
Article in Journal of oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present.Journal of ovarian research · 2022Pooled it
- Article
- Dualistic classification of high grade serous ovarian carcinoma has its root in spatial heterogeneity.Journal of advanced research · 2023Article
- Synchronous bilateral primary ovarian cancer with right endometroid carcinoma and left high-grade serous carcinoma: a case report and literature review.BMC women's health · 2022Review
- Radiomics based on multisequence magnetic resonance imaging for the preoperative prediction of peritoneal metastasis in ovarian cancer.European radiology · 2021Article
- Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Histopathological Pattern and Age Distribution, of Malignant Ovarian Tumor among Sudanese Ladies.Open access Macedonian journal of medical sciences · 2018Article
- Involvement of DPP9 in gene fusions in serous ovarian carcinoma.BMC cancer · 2017Article
- Bilateral ovarian carcinomas differ in the expression of metastasis-related genes.Oncology letters · 2017Article
- New models of hematogenous ovarian cancer metastasis demonstrate preferential spread to the ovary and a requirement for the ovary for abdominal dissemination.Translational research : the journal of laboratory and clinical medicine · 2016Article
- Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes.Oncotarget · 2015Article
- Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Genomic profile of ovarian carcinomas.BMC cancer · 2014Article
- Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium.Oncogene · 2012Article
- A new branch on the tree: next-generation sequencing in the study of cancer evolution.Seminars in cell & developmental biology · 2012Review
- Safety of ovarian tissue autotransplantation for cancer patients.Obstetrics and gynecology international · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer of the ovary is bilateral in 25%. Cytogenetic analysis could determine whether the disease in bilateral cases is metastatic or two separately occurring primary tumors, but karyotypic information comparing the two cancerous ovaries is limited to a single report with 11 informative cases. We present a series of 32 bilateral ovarian carcinoma cases, analyzed by karyotyping and high-resolution CGH. Our karyotypic findings showed that spreading to the contralateral ovary had occurred in bilateral ovarian cancer cases and that it was a late event in the clonal evolution of the tumors. This was confirmed by the large number of similar changes detected by HR-CGH in the different lesions from the same patient. The chromosomal bands most frequently involved in structural rearrangements were 19p13 (n = 12) and 19q13 (n = 11). The chromosomal bands most frequently gained by both tumorous ovaries were 5p14 (70%), 8q23-24 (65%), 1q23-24 (57%), and 12p12 (48%), whereas the most frequently lost bands were 17p11 (78%), 17p13 (74%), 17p12 (70%), 22q13 (61%), 8p21 and 19q13 (52%), and 8p22-23 (48%). This is the first time that 5p14 is seen gained at such a high frequency in cancer of the ovary; possibly oncogene(s) involved in bilateral ovarian carcinogenesis or tumor progression may reside in this band.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.