ArticleNature2009
Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling.
Article in Nature, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
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Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Genome-wide association study of obsessive-compulsive disorder.Molecular psychiatry · 2013Pooled it
- Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration.Nature communications · 2025Article
- Src/Fas2-dependent Ephrin phosphorylation initiates Eph/Ephrin reverse signaling through Rac1 to shape columnar units in the fly brain.Science advances · 2025Article
- Prdm16 regulates the postnatal fate of embryonic radial glia via Vcam1-dependent mechanisms.Nature communications · 2025Article
- Radial Microbrain (Micrencephaly) Is Caused by a Recurrent Variant in theNeurology. Genetics · 2025Article
- Developmental trajectories of GABAergic cortical interneurons are sequentially modulated by dynamicProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Overexpression of EphB6 and EphrinB2 controls soma spacing of cortical neurons in a mutual inhibitory way.Cell death & disease · 2023Article
- Thalamocortical circuits for the formation of hierarchical pathways in the mammalian visual cortex.Frontiers in neural circuits · 2023Review
- Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.PLoS computational biology · 2021Article
- Deciphering neural heterogeneity through cell lineage tracing.Cellular and molecular life sciences : CMLS · 2021Review
- Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner.Frontiers in molecular neuroscience · 2021Article
- Expression of FLRT2 in Postnatal Central Nervous System Development and After Spinal Cord Injury.Frontiers in molecular neuroscience · 2021Article
- Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.Frontiers in molecular neuroscience · 2021Article
- Review
- Dual Role of Rbpj in the Maintenance of Neural Progenitor Cells and Neuronal Migration in Cortical Development.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Article
- Article
- FLRTing Neurons in Cortical Migration During Cerebral Cortex Development.Frontiers in cell and developmental biology · 2020Review
- Integrating Clinical and Genomic Analyses of Hippocampal-Prefrontal Circuit Disorder in Depression.Frontiers in genetics · 2020Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cerebral cortex is a laminated sheet of neurons composed of the arrays of intersecting radial columns. During development, excitatory projection neurons originating from the proliferative units at the ventricular surface of the embryonic cerebral vesicles migrate along elongated radial glial fibres to form a cellular infrastructure of radial (vertical) ontogenetic columns in the overlaying cortical plate. However, a subpopulation of these clonally related neurons also undergoes a short lateral shift and transfers from their parental to the neighbouring radial glial fibres, and intermixes with neurons originating from neighbouring proliferative units. This columnar organization acts as the primary information processing unit in the cortex. The molecular mechanisms, role and significance of this lateral dispersion for cortical development are not understood. Here we show that an Eph receptor A (EphA) and ephrin A (Efna) signalling-dependent shift in the allocation of clonally related neurons is essential for the proper assembly of cortical columns. In contrast to the relatively uniform labelling of the developing cortical plate by various molecular markers and retrograde tracers in wild-type mice, we found alternating labelling of columnar compartments in Efna knockout mice that are caused by impaired lateral dispersion of migrating neurons rather than by altered cell production or death. Furthermore, in utero electroporation showed that lateral dispersion depends on the expression levels of EphAs and ephrin-As during neuronal migration. This so far unrecognized mechanism for lateral neuronal dispersion seems to be essential for the proper intermixing of neuronal types in the cortical columns, which, when disrupted, might contribute to neuropsychiatric disorders associated with abnormal columnar organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.