ArticleBlood2009
Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model.
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Healthy and premature aging of monocytes and macrophages.Frontiers in immunology · 2025Review
- A mysterious triangle of blood, bones, and nerves.Journal of bone and mineral metabolism · 2023Review
- Tumor-derived interleukin-1α and leukemia inhibitory factor promote extramedullary hematopoiesis.PLoS biology · 2023Article
- Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway.EMBO reports · 2023Article
- Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis.Haematologica · 2020Article
- Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis.Haematologica · 2018Review
- Multicolor quantitative confocal imaging cytometry.Nature methods · 2018Article
- HSC Niche Biology and HSC Expansion Ex Vivo.Trends in molecular medicine · 2017Review
- Review
- Regulation of hematopoietic stem cells by bone marrow stromal cells.Trends in immunology · 2014Review
- Cellular complexity of the bone marrow hematopoietic stem cell niche.Calcified tissue international · 2014Review
- Stem cells supporting other stem cells.Frontiers in genetics · 2013Review
- Engraftment Outcomes after HPC Co-Culture with Mesenchymal Stromal Cells and Osteoblasts.Journal of clinical medicine · 2013Article
- Concise review: Current concepts in bone marrow microenvironmental regulation of hematopoietic stem and progenitor cells.Stem cells (Dayton, Ohio) · 2013Review
- Myeloid skewing in murine autoimmune arthritis occurs in hematopoietic stem and primitive progenitor cells.Blood · 2012Article
- N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.Blood · 2012Article
- Article
- The hematopoietic stem cell niche.Frontiers in bioscience (Landmark edition) · 2012Review
- Hematopoietic stem cell development, niches, and signaling pathways.Bone marrow research · 2012Article
- The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization.Leukemia · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Recent studies support the notion that there is an intricate relationship between hematopoiesis and bone homeostasis in normal steady states. Using mice undergoing chronic inflammatory arthritis, we investigated the relationship between hematopoiesis and bone homeostasis in pathologic conditions. We demonstrate that mice undergoing chronic inflammatory arthritis displayed osteoporosis resulting from a severe defect in osteoblast function. Despite the defective osteoblast function, however, the hematopoietic stem cells from these mice exhibited normal properties in either long-term repopulation or cell cycling. Therefore, the bone-forming capacity of osteoblasts is distinct from their ability to maintain hematopoietic stem cells in chronic inflammatory conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.