ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
Mice lacking the G protein gamma3-subunit show resistance to opioids and diet induced obesity.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- A consensus guide to preclinical indirect calorimetry experiments.Nature metabolism · 2025Review
- The impact of opioids on the transcriptional landscape of human villous trophoblasts.Placenta · 2023Article
- Investigation of candidate genes and mechanisms underlying obesity associated type 2 diabetes mellitus using bioinformatics analysis and screening of small drug molecules.BMC endocrine disorders · 2021Article
- Promoter Hypomethylation of TGFBR3 as a Risk Factor of Alzheimer's Disease: An Integrated Epigenomic-Transcriptomic Analysis.Frontiers in cell and developmental biology · 2021Article
- Gene Expression Profiling of Type 2 Diabetes Mellitus by Bioinformatics Analysis.Computational and mathematical methods in medicine · 2020Article
- G-protein-coupled receptor signaling and neural tube closure defects.Birth defects research · 2017Review
- Gγ7 proteins contribute to coupling of nociceptin/orphanin FQ peptide (NOP) opioid receptors and voltage-gated Ca(2+) channels in rat stellate ganglion neurons.Neuroscience letters · 2016Article
- Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy.Human molecular genetics · 2016Article
- Structural Analysis of PTM Hotspots (SAPH-ire)--A Quantitative Informatics Method Enabling the Discovery of Novel Regulatory Elements in Protein Families.Molecular & cellular proteomics : MCP · 2015Article
- Metabolic vs. hedonic obesity: a conceptual distinction and its clinical implications.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Review
- Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.Cellular signalling · 2014Article
- The neuroanatomy of sexual dimorphism in opioid analgesia.Experimental neurology · 2014Review
- Differential localization of G protein βγ subunits.Biochemistry · 2014Article
- Article
- Synergistic roles for G-protein γ3 and γ7 subtypes in seizure susceptibility as revealed in double knock-out mice.The Journal of biological chemistry · 2012Article
- Metabolic and hedonic drives in the neural control of appetite: who is the boss?Current opinion in neurobiology · 2011Review
- Adenosine A2A receptor signaling and golf assembly show a specific requirement for the gamma7 subtype in the striatum.The Journal of biological chemistry · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Contributing to the obesity epidemic, there is increasing evidence that overconsumption of high-fat foods may be analogous to drug addiction in that the palatability of these foods is associated with activation of specific reward pathways in the brain. With this perspective, we report that mice lacking the G protein gamma(3)-subunit (Gng3(-/-) mice) show resistance to high-fat diet-induced weight gain over the course of a 12-wk study. Compared with Gng3(+/+) controls, female Gng3(-/-) mice exhibit a 40% reduction in weight gain and a 53% decrease in fat pad mass, whereas male Gng3(-/-) mice display an 18% reduction in weight gain and no significant decrease in fat pad mass. The basis for the lowered weight gain is related to reduced food consumption for female and male Gng3(-/-) mice of 13% and 14%, respectively. Female Gng3(-/-) mice also show a lesser preference for high-fat chow than their female Gng3(+/+) littermates, suggesting an attenuated effect on a reward pathway associated with overconsumption of fat. One possible candidate is the micro-opioid receptor (Oprm1) signaling cascade. Supporting a defect in this signaling pathway, Gng3(-/-) mice show marked reductions in both acute and chronic morphine responsiveness, as well as increases in endogenous opioid mRNA levels in reward-related regions of the brain. Taken together, these data suggest that the decreased weight gain of Gng3(-/-) mice may be related to a reduced rewarding effect of the high-fat diet resulting from a defect in Oprm1 signaling and loss of the G protein gamma(3)-subunit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.