ArticleJournal of neurophysiology2009
Locally balanced dendritic integration by short-term synaptic plasticity and active dendritic conductances.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Quantifying the Number of Discriminable Coincident Dendritic Input Patterns through Dendritic Tree Morphology.Scientific reports · 2015Article
- Cellular biomechanics of central nervous system injury.Handbook of clinical neurology · 2015Review
- An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2014Article
- The DIADEM data sets: representative light microscopy images of neuronal morphology to advance automation of digital reconstructions.Neuroinformatics · 2011Review
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The high degree of variability observed in spike trains and membrane potentials of pyramidal neurons in vivo is thought to be a consequence of a balance between excitatory and inhibitory inputs, which depends on the dynamics of the network. We simulated synaptic currents and ion channels in a reconstructed hippocampal CA1 pyramidal cell and show here that a local balance can be achieved on a dendritic branch with a different mechanism, based on presynaptic depression of quantal release interacting with active dendritic conductances. This mechanism, which does not require synaptic inhibition, allows each dendritic branch to remain sensitive to correlated synaptic inputs, induces a high degree of variability in the output spike train, and can be combined with other balance mechanisms based on network dynamics. This hypothesis makes a testable prediction for the cause of the observed variability in the firing of hippocampal place cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.