ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Negative shift in the glycine reversal potential mediated by a Ca2+- and pH-dependent mechanism in interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Amelioration of obsessive-compulsive disorder by intracellular acidification of cortical neurons with a proton pump inhibitor.Translational psychiatry · 2024Article
- Inhibitory interneurons in a brainstem circuit adjust their inhibitory motifs to process multimodal input.The Journal of physiology · 2021Article
- Inhibition of GluR Current in Microvilli of Sensory Neurons via NaFrontiers in cellular neuroscience · 2018Article
- Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment.Cell reports · 2017Article
- Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Spontaneous Activity Defines Effective Convergence Ratios in an Inhibitory Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Proton-mediated block of Ca2+ channels during multivesicular release regulates short-term plasticity at an auditory hair cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- GABAergic and glycinergic inhibitory synaptic transmission in the ventral cochlear nucleus studied in VGAT channelrhodopsin-2 mice.Frontiers in neural circuits · 2014Article
- Anion transport and GABA signaling.Frontiers in cellular neuroscience · 2013Review
- The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters.Physiological reviews · 2013Review
- Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Intrinsic and synaptic properties of vertical cells of the mouse dorsal cochlear nucleus.Journal of neurophysiology · 2012Article
- Estimating three synaptic conductances in a stochastic neural model.Journal of computational neuroscience · 2012Article
- The sodium-driven chloride/bicarbonate exchanger in presynaptic terminals.The Journal of comparative neurology · 2012Article
- Role of pH in a nitric oxide-dependent increase in cytosolic Cl- in retinal amacrine cells.Journal of neurophysiology · 2011Article
- Synaptic glutamate release is modulated by the Na+ -driven Cl-/HCO₃⁻ exchanger Slc4a8.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans.The EMBO journal · 2011Article
- Vesicular glutamate transporters: spatio-temporal plasticity following hearing loss.Neuroscience · 2011Article
- Somatosensory context alters auditory responses in the cochlear nucleus.Journal of neurophysiology · 2011Article
- Depolarizing actions of GABA in immature neurons depend neither on ketone bodies nor on pyruvate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Cartwheel cells are glycinergic auditory interneurons which fire Na(+)- and Ca(2+)-dependent spike bursts, termed complex spikes, and which synapse on both principal cells and one another. The reversal potential for glycine (E(gly)) can be hyperpolarizing or depolarizing in cartwheel cells, and many cells are even excited by glycine. We explored the role of spike activity in determining E(gly) in mouse cartwheel cells using gramicidin perforated-patch recording. E(gly) was found to shift toward more negative potentials after a period of complex spiking or Ca(2+) spiking induced by depolarization, thus enhancing glycine's inhibitory effect for approximately 30 s following cessation of spiking. Combined perforated patch electrophysiology and imaging studies showed that the negative E(gly) shift was triggered by a Ca(2+)-dependent intracellular acidification. The effect on E(gly) was likely caused by bicarbonate-Cl(-) exchanger-mediated reduction in intracellular Cl(-), as H(2)DIDS and removal of HCO(3)(-)/CO(2) inhibited the negative E(gly) shift. The outward Cl(-) flux underlying the negative shift in E(gly) opposed a positive shift triggered by passive Cl(-) redistribution during the depolarization. Thus, a Ca(2+)-dependent mechanism serves to maintain or enhance the strength of inhibition in the face of increased excitatory activity.
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