ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Modeling primary microcephaly with human brain organoids reveals fundamental roles of CIT kinase activity.The Journal of clinical investigation · 2024Article
- Apical-basal polarity and the control of epithelial form and function.Nature reviews. Molecular cell biology · 2022Review
- The Roles of Par3, Par6, and aPKC Polarity Proteins in Normal Neurodevelopment and in Neurodegenerative and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Coordinated assembly and release of adhesions builds apical junctional belts duringDevelopment (Cambridge, England) · 2020Article
- Notch-mediated inhibition of neurogenesis is required for zebrafish spinal cord morphogenesis.Scientific reports · 2019Article
- Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate.Scientific reports · 2019Article
- Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease.Neurochemical research · 2019Review
- Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation.iScience · 2018Article
- Microtubules, polarity and vertebrate neural tube morphogenesis.Journal of anatomy · 2016Review
- Spatial-temporal expressions of Crumbs and Nagie oko and their interdependence in zebrafish central nervous system during early development.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
- Developmental time rather than local environment regulates the schedule of epithelial polarization in the zebrafish neural rod.Neural development · 2013Article
- Neurogenesis in zebrafish - from embryo to adult.Neural development · 2013Review
- Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod.The EMBO journal · 2013Article
- Fluorescently tagged Lin7c is a dynamic marker for polarity maturation in the zebrafish retinal epithelium.Biology open · 2013Article
- Apicobasal polarity and neural tube closure.Development, growth & differentiation · 2013Review
- Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Crb apical polarity proteins maintain zebrafish retinal cone mosaics via intercellular binding of their extracellular domains.Developmental cell · 2012Article
- Bone morphogenetic proteins regulate neural tube closure by interacting with the apicobasal polarity pathway.Development (Cambridge, England) · 2011Article
- Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movements.Development (Cambridge, England) · 2011Article
- Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
During vertebrate neurulation, extensive cell movements transform the flat neural plate into the neural tube. This dynamic morphogenesis requires the tissue to bear a certain amount of plasticity to accommodate shape and position changes of individual cells as well as intercellular cohesiveness to maintain tissue integrity and architecture. For most of the neural plate-neural tube transition, cells are polarized along the apicobasal axis. The establishment and maintenance of this polarity requires many polarity proteins that mediate cell-cell adhesion either directly or indirectly. Intercellular adhesion reduces tissue plasticity and enhances tissue integrity. However, it remains unclear how apicobasal polarity is regulated to meet the opposing needs for tissue plasticity and tissue integrity during neurulation. Here, we show that N-Cad/ZO-1 complex-initiated apicobasal polarity is stabilized by the late-onsetting Lin7c/Nok complex after the extensive morphogenetic cell movements in neurulation. Loss of either N-Cad or Lin7c disrupts neural tube formation. Furthermore, precocious overexpression of Lin7c induces multiaxial mirror symmetry in zebrafish neurulation. Our data suggest that stepwise maturation of apicobasal polarity plays an essential role in vertebrate neurulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.