ArticleAmerican journal of physiology. Renal physiology2009
Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats.
Article in American journal of physiology. Renal physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol.Clinical interventions in aging · 2019Trial
- The effects of high intensity interval training induced HJournal of diabetes and metabolic disorders · 2024Article
- The Potential Modulatory Effects of Exercise on Skeletal Muscle Redox Status in Chronic Kidney Disease.International journal of molecular sciences · 2023Review
- Age-Related Mitochondrial Impairment and Renal Injury Is Ameliorated by Sulforaphane via Activation of Transcription Factor NRF2.Antioxidants (Basel, Switzerland) · 2022Article
- Non-invasive Assessment of Fecal Stress Biomarkers in Hunting Dogs During Exercise and at Rest.Frontiers in veterinary science · 2020Article
- Renoprotective effects of voluntary running exercise training on aldosterone-induced renal injury in human L-FABP chromosomal transgenic mice.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Role of Thioredoxin 1 in Impaired Renal Sodium Excretion of hDJournal of the American Heart Association · 2019Article
- Trimetazidine Attenuates Exhaustive Exercise-Induced Myocardial Injury in Rats via Regulation of the Nrf2/NF-κB Signaling Pathway.Frontiers in pharmacology · 2019Article
- Heme oxygenase activity increases after exercise in healthy volunteers.Free radical research · 2018Article
- Capsaicinoids improve consequences of physical activity.Toxicology reports · 2018Article
- Nrf2 mediates redox adaptations to exercise.Redox biology · 2016Review
- Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats.Oxidative medicine and cellular longevity · 2016Article
- Oxidative stress response and Nrf2 signaling in aging.Free radical biology & medicine · 2015Review
- Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system.Journal of signal transduction · 2014Review
- Anti-inflammatory effect of recreational exercise in TNBS-induced colitis in rats: role of NOS/HO/MPO system.Oxidative medicine and cellular longevity · 2014Article
- Renal dopamine receptors, oxidative stress, and hypertension.International journal of molecular sciences · 2013Review
- Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling.Antioxidants & redox signaling · 2013Review
- Renal dopamine and angiotensin II receptor signaling in age-related hypertension.American journal of physiology. Renal physiology · 2013Review
- Novel role of NF-κB-p65 in antioxidant homeostasis in human kidney-2 cells.American journal of physiology. Renal physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have previously reported that age-associated oxidative stress via protein kinase C (PKC) increases D1 receptor (D1R) phosphorylation and causes D1R-G protein uncoupling in renal proximal tubules (RPTs) of old Fischer 344 rats. This results in reduced ability of D1R agonist SKF-38393 to inhibit Na+-K+-ATPase in RPTs of old rats. Here, we studied the effect of treadmill exercise on markers of oxidative stress, PKC, D1R phosphorylation, D1R-G protein coupling, and Na+-K+-ATPase activity in RPTs of adult and old rats. We found increased levels of malondialdehyde, a marker of oxidative stress, in RPTs of old rats, which decreased during exercise. Nuclear levels of nuclear erythroid-related factor (Nrf)-2 and nuclear factor (NF)-kappaB in RPTs, transcription factors involved in antioxidant enzyme gene transcription, increased in exercised old rats. This was accompanied by an increase in the activity and expression of antioxidant enzymes, superoxide dismutase and heme oxygenase-1. Age-related decrease in the levels of D1R mRNAs and proteins was attenuated during exercise. Furthermore, exercise in old rats decreased PKC activity and D1R phosphorylation and increased SKF-38393-mediated [35S]guanosine 5'-O-(3-thiotriphosphate) binding (an index of D1R-G protein coupling). SKF-38393 also caused inhibition of Na+-K+-ATPase in these animals. Also, exercise caused a decrease in proteinuria and increase in phosphaturia in old rats. These results suggest beneficial effects of exercise in terms of increasing antioxidant defenses, decreasing oxidative stress, and improving kidney function in general and D1R function in particular in aging. Both Nrf-2 and NF-kappaB seem to play key role in this phenomenon.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.