Evidence map›Paper›PMID 19759250›Full record

ArticleClinical and vaccine immunology : CVI2009

Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin.

John M Thomas, Scott T Moen, Bryan T Gnade, Diego A Vargas-Inchaustegui, Sheri M Foltz, Giovanni Suarez, Hans W Heidner, Rolf König, Ashok K Chopra, Johnny W Peterson

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  4. Review
  5. RNA-based drugs and vaccines.Expert review of vaccines · 2015
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

John M ThomasDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555-1070, USA. JohnM.Thomas@utsouthwestern.edu
Scott T Moen
Bryan T Gnade
Diego A Vargas-Inchaustegui
Sheri M Foltz
Giovanni Suarez
Hans W Heidner
Rolf König
Ashok K Chopra
Johnny W Peterson
John Sealy Hospital · USThe University of Texas at San Antonio · US

Funding

NIAID NIH HHS 1N01AI30065NIAID NIH HHS N01 AI030065
6 · The paper itself

Abstract

Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.

Indexed as

Genetic VectorsAnimalsAnthraxAnthrax VaccinesAnti-Bacterial AgentsAntibodies, BacterialAntibodies, NeutralizingAntigens, BacterialBacillus anthracisBacterial ToxinsCiprofloxacinHumansImmunoglobulin GMiceSindbis VirusSurvival Analysisanthrax toxinAnthrax VaccinesAnti-Bacterial AgentsAntibodies, BacterialAntibodies, NeutralizingAntigens, BacterialBacterial ToxinsCiprofloxacinImmunoglobulin GVaccines, Synthetic

Identifiers

PMID19759250
PMCPMC2772374
OpenAlexW2124866632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.