ArticleInternational journal of experimental pathology2009
Gamma-delta T cell subsets are differentially associated with granuloma development and organization in a bovine model of mycobacterial disease.
Article in International journal of experimental pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Jejunal mucosal immune response in goats ten months afterThe veterinary quarterly · 2026Article
- Paratuberculosis: a mucosal immunology perspective.Frontiers in immunology · 2026Review
- The Crosstalk BetweenCells · 2025Review
- T Cell Responses to Influenza Infections in Cattle.Viruses · 2025Review
- γδ T cell distribution in the adventitial layer of non-fertile cystic echinococcosis cysts from cattle livers.Scientific reports · 2025Article
- Article
- Stage of infection withFrontiers in veterinary science · 2023Article
- Bovine Immunity and Vitamin DMicroorganisms · 2022Review
- Local assessment of the immunohistochemical expression of Foxp3BMC veterinary research · 2022Article
- Johne's Disease in Dairy Cattle: An Immunogenetic Perspective.Frontiers in veterinary science · 2021Review
- Modelling Bovine Granuloma Formation In Vitro upon Infection withVeterinary sciences · 2019Article
- Emerging role of γδ T cells in vaccine-mediated protection from infectious diseases.Clinical & translational immunology · 2019Review
- Measuring bovine γδ T cell function at the site of Mycobacterium bovis infection.Veterinary immunology and immunopathology · 2017Article
- Bovine WC1Frontiers in immunology · 2017Article
- Animal Models for Tuberculosis in Translational and Precision Medicine.Frontiers in microbiology · 2017Review
- γδ T Cells and dendritic cells in refractory Lyme arthritis.Journal of leukocyte biology · 2015Review
- Host Transcriptional Profiles and Immunopathologic Response following Mycobacterium avium subsp. paratuberculosis Infection in Mice.PloS one · 2015Article
- Article
- Comparative gamma delta T cell immunology: a focus on mycobacterial disease in cattle.Veterinary medicine international · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characteristic lesion in bovine tuberculosis is well-organized respiratory granulomas. This is typically associated with a strong T-helper 1 biased cell-mediated immune response and eventual containment of the infection. In bovine paratuberculosis, the classic lesion is unorganized granulomatous intestinal inflammation. Clinical paratuberculosis is associated with a T-helper 2 biased humoral immune response and eventual death because of inability of the host to contain the infection. Recent reports have suggested that gamma-delta (gammadelta) T cells play a significant role in granuloma development and/or maintenance during initial stages of infection and may influence the subsequent adaptive immune response. The objective of this study was to use an in vivo bovine model to evaluate gammadelta T cells during the early host immune response to mycobacterial infection. We used immunofluorescent staining, hyperspectral microscopy, and computerized assisted morphometry to evaluate staining and distribution of gammadelta T cells during development of organized and unorganized granulomas. Our data suggest that bovine gammadelta T cell subsets are differentially recruited to early infection sites, and may be instrumental during the initial antimycobacterial host immune response as well as for granuloma organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.