ArticleJournal of vision2009
Inter-ocular contrast normalization in human visual cortex.
Article in Journal of vision, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Continuous flash suppression modulates cortical activity in early visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- A monocular contribution to stimulus rivalry.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Bistable percepts in the brain: FMRI contrasts monocular pattern rivalry and binocular rivalry.PloS one · 2011Trial
- Ocularity modulates the dominance of spatial over temporal influences in binocular rivalry.Journal of vision · 2026Article
- Eye-specific drive and binocular suppression in mouse visual cortex during critical period development.bioRxiv : the preprint server for biology · 2026Article
- Binocular combination in the autonomic nervous system.PloS one · 2026Article
- Significant Age-Related Visual Declines but Preserved Binocular Summation of Contrast Sensitivity and Visual Acuity Across Adulthood.Investigative ophthalmology & visual science · 2025Article
- The latent mechanism behind binocular advantage in reading.Journal of vision · 2025Article
- Interocular suppression in chromoluminance patterns measured with SSVEP.Journal of vision · 2025Article
- Contextual Binocular Imbalance Impairs Local Stereopsis.Investigative ophthalmology & visual science · 2025Article
- Binocular integration of chromatic and luminance signals.Journal of vision · 2024Article
- BOLD Contrast Response Characteristics of Aberrant Voxels with Bilateral Visual Population Receptive Fields in Human Albinism.bioRxiv : the preprint server for biology · 2024Article
- Ocular dominance-dependent binocular combination of monocular neuronal responses in macaque V1.eLife · 2024Article
- Different rules for binocular combination of luminance flicker in cortical and subcortical pathways.eLife · 2023Article
- A role for ocular dominance in binocular integration.Current biology : CB · 2023Article
- Characterizing amblyopic perception under non-rivalrous viewing conditions.Scientific reports · 2023Article
- Azimuthal invariance to looming stimuli in the Drosophila giant fiber escape circuit.The Journal of experimental biology · 2023Article
- Binocular summation in high and low contrast letter acuities.Frontiers in neuroscience · 2023Article
- Cortical field maps across human sensory cortex.Frontiers in computational neuroscience · 2023Review
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6 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
The brain combines visual information from the two eyes and forms a coherent percept, even when inputs to the eyes are different. However, it is not clear how inputs from the two eyes are combined in visual cortex. We measured fMRI responses to single gratings presented monocularly, or pairs of gratings presented monocularly or dichoptically with several combinations of contrasts. Gratings had either the same orientation or orthogonal orientations (i.e., plaids). Observers performed a demanding task at fixation to minimize top-down modulation of the stimulus-evoked responses. Dichoptic presentation of compatible gratings (same orientation) evoked greater activity than monocular presentation of a single grating only when contrast was low (<10%). A model that assumes linear summation of activity from each eye failed to explain binocular responses at 10% contrast or higher. However, a model with binocular contrast normalization, such that activity from each eye reduced the gain for the other eye, fitted the results very well. Dichoptic presentation of orthogonal gratings evoked greater activity than monocular presentation of a single grating for all contrasts. However, activity evoked by dichoptic plaids was equal to that evoked by monocular plaids. Introducing an onset asynchrony (stimulating one eye 500 ms before the other, which under attentive vision results in flash suppression) had no impact on the results; the responses to dichoptic and monocular plaids were again equal. We conclude that when attention is diverted, inter-ocular suppression in V1 can be explained by a normalization model in which the mutual suppression between orthogonal orientations does not depend on the eye of origin, nor on the onset times, and cross-orientation suppression is weaker than inter-ocular (same orientation) suppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.