Evidence map›Paper›PMID 19757859›Full record

ReviewSports medicine (Auckland, N.Z.)2009

The effect of physical exercise on endothelial function.

Samanta Di Francescomarino, Adolfo Sciartilli, Valentina Di Valerio, Angela Di Baldassarre, Sabina Gallina

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 13 pooled it
58.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 13 syntheses or guidelines pooled it, 365 citations in OpenAlex.

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  12. Competitive sports and the heart: benefit or risk?Deutsches Arzteblatt international · 2013
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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Samanta Di FrancescomarinoDepartment of Clinical Science and Bioimaging, University of Chieti, Chieti, Italy.
Adolfo Sciartilli
Valentina Di Valerio
Angela Di Baldassarre
Sabina Gallina
University of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelium is essential for maintenance of health of the vessel wall and for the local regulation of vascular tone and structure and haemostasis. Regular physical exercise, which is known to promote a favourable cardiovascular state, may improve endothelial function via several mechanisms. Indeed, it augments blood flow and laminar shear stress, resulting in increased nitric oxide production and bioavailability. In this regard, the beneficial effects of training on endothelial function can be mediated in a number of ways, including synthesis of molecular mediators, changes in neurohormonal release and oxidant/antioxidant balance. On the other hand, physical exercise can also elicit systemic molecular pathways connected with angiogenesis and chronic anti-inflammatory action with consequent modification of the endothelial function. However, its benefit depends on the type and intensity of training performed. While strenuous exercise increases oxidative metabolism and produces a pro-oxidant environment, only regular moderate physical activity promotes an antioxidant state and preserves endothelial function. Thus, exercise may have a beneficial effect on the development of cardiovascular disease through preserving endothelial function.

Indexed as

AgingCardiovascular DiseasesCell Adhesion MoleculesEicosanoidsEndothelin-1Endothelium, VascularExerciseHumansMyocytes, Smooth MuscleNeovascularization, PhysiologicNitric OxideOxidative PhosphorylationOxidative StressShear StrengthStress, PhysiologicalTissue Plasminogen ActivatorCell Adhesion MoleculesEicosanoidsEndothelin-1Nitric OxideTissue Plasminogen Activator

Identifiers

PMID19757859
OpenAlexW2021292277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.