ReviewNeuromolecular medicine2009
Are there common biochemical and molecular mechanisms controlling manganism and parkisonism.
Review in Neuromolecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 83 citations in OpenAlex.
- Review
- Non-invasive radionuclide imaging of trace metal trafficking in health and disease: "PET metallomics".RSC chemical biology · 2022Review
- Gut Microbiota as a Potential Player in Mn-Induced Neurotoxicity.Biomolecules · 2021Review
- The effects of manganese overexposure on brain health.Neurochemistry international · 2020Review
- Thiamine Deficiency Modulates p38Neurochemical research · 2020Article
- The Role of Xenobiotics and Trace Metals in Parkinson's Disease.Molecular neurobiology · 2020Review
- DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration.Frontiers in neuroscience · 2019Review
- Reduced expression of PARK2 in manganese-exposed smelting workers.Neurotoxicology · 2017Article
- Exploring Manganese Fractionation Using a Sequential Extraction Method to Evaluate Welders' Gas Metal Arc Welding Exposures during Heavy Equipment Manufacturing.Annals of work exposures and health · 2017Article
- Environmental Exposures and Parkinson's Disease.International journal of environmental research and public health · 2016Review
- Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.Nature communications · 2016Article
- Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation.Metallomics : integrated biometal science · 2015Article
- KHSRP participates in manganese-induced neurotoxicity in rat striatum and PC12 cells.Journal of molecular neuroscience : MN · 2015Article
- Manganese Fractionation Using a Sequential Extraction Method to Evaluate Welders' Shielded Metal Arc Welding Exposures During Construction Projects in Oil Refineries.Journal of occupational and environmental hygiene · 2015Article
- A zebrafish model of manganism reveals reversible and treatable symptoms that are independent of neurotoxicity.Disease models & mechanisms · 2014Article
- Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity.Neurotoxicology · 2014Article
- Effects of developmental manganese, stress, and the combination of both on monoamines, growth, and corticosterone.Toxicology reports · 2014Article
- Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis.PloS one · 2014Article
- Genetic factors and manganese-induced neurotoxicity.Frontiers in genetics · 2014Review
- The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism.Neurotoxicology · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past several decades there has been considerable progress in our basic knowledge as to the mechanisms and factors regulating Mn toxicity. The disorder known as manganism is associated with the preferential accumulation of Mn in the globus pallidus of the basal ganglia which is generally considered to be the major and initial site of injury. Because the area of the CNS comprising the basal ganglia is very complex and dependent on the precise function and balance of several neurotransmitters, it is not surprising that symptoms of manganism often overlap with that of Parkinson's disease. The fact that neurological symptoms and onset of Mn toxicity are quite broad and can vary unpredictably probably reflects specific genetic variance of the physiological and biochemical makeup within the basal ganglia in any individual. Differences in response to Mn overexposure are, thus, likely due to underlying genetic variability which ultimately presents in deviations in both susceptibility as well as the characteristics of the neurological lesions and symptoms expressed. Although chronic exposure to Mn is not the initial causative agent provoking Parkinsonism, there is evidence suggesting that persistent exposure can predispose an individual to acquire dystonic movements associated with Parkinson's disease. As noted in this review, there appears to be common threads between the two disorders, as mutations in the genes, parkin and ATP13A2, associated with early onset of Parkinsonism, may also predispose an individual to develop Mn toxicity. Mutations in both genes appear to effect transport of Mn into the cell. These genetic difference coupled with additional environmental or nutritional factors must also be considered as contributing to the severity and onset of manganism.
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