ArticleMolecular biology reports2010
Differential expression of TRPC channels in the left ventricle of spontaneously hypertensive rats.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy.Biomolecules · 2024Article
- TRPC5 channel participates in myocardial injury in chronic intermittent hypoxia.Clinics (Sao Paulo, Brazil) · 2024Article
- TRPC5 as a possible therapeutic target for vascular dysfunction associated with obesity.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- TRPC5 mediates endothelium-dependent contraction in the carotid artery of diet-induced obese mice.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Review
- Effect of surgical castration on expression of TRPM8 in urogenital tract of male rats.Molecular biology reports · 2012Article
- Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1.Current drug targets · 2011Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was designed to identify the differential expression of the canonical transient receptor potential (TRPC) channels in the left ventricle of spontaneously hypertensive rats (SHR). Echocardiography studies were performed to compare the left ventricular function in SHR vs. Wistar-Kyoto rats (WKY), and the mRNA level of the TRPC channels was determined by quantitative real-time RT-PCR (qRT-PCR). Western blots were performed to examine whether the mRNA expression corresponded with the protein expression. Compared with the WKY, the mRNA expression of TRPC4 and TRPC5 was significantly increased in the 10-week-old SHR (P = 0.032 for TRPC4 and P = 0.043 for TRPC5), so did the TRPC4/5 protein content. The midwall fractional shortening (mFS) of SHR was lower than WKY (P = 0.016). Furthermore, increased expression of TRPC4/5 was correlated with both increased blood pressure and decreased mFS. These findings suggest that TRPC4 and 5 seem to be the main subtypes expressed in the heart of the SHR at the beginning period of hypertension. Theses channels may participate in the development of left ventricular systolic dysfunction.
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Registered trials
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