ArticleMolecular biology reports2010
Characterization of a novel human HMBOX1 splicing variant lacking the homeodomain and with attenuated transcription repressor activity.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway.Cellular & molecular immunology · 2011Article
- Expression profile of HMBOX1, a novel transcription factor, in human cancers using highly specific monoclonal antibodies.Experimental and therapeutic medicine · 2011Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
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Abstract
We previously identified the human HMBOX1 (homeobox containing 1) gene, which represents a distinct group of HNF transcription factors, and is a potential transcription repressor with highly expression in pancreas. In our present work, we found that there exists a splicing variant of HMBOX1, designated HMBOX1b. Compared to HMBOX1, HMBOX1b encodes a 304 amino acids protein that shares the N-terminal region but has no homeodomain and the C-terminal region because of an alternative exon 7 which results in reading frame shifting. Unlike the highly pancreatic expression of HMBOX1, HMBOX1b was ubiquitous expressed in all human tissues detected by RT-PCR. Immunofluorescence staining showed that HMBOX1b accumulated in both cytoplasm and nucleus, and transcriptional reporter assays indicated that HMBOX1b only retained faint transcriptional repressive activity. Taken together, our findings suggest a distinct role of HMBOX1b, and the control of mRNA splicing might be involved in homeobox genes regulation.
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