ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2010
An anti-inflammatory lectin from Luetzelburgia auriculata seeds inhibits adhesion and rolling of leukocytes and modulates histamine and PGE2 action in acute inflammation models.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Wound healing and anti-inflammatory effects of LAA, the N-acetyl-D-galactosamine-binding lectin from seeds of Luetzelburgia auriculata (Allemão) ducke.Histochemistry and cell biology · 2025Article
- A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal Health.Current issues in molecular biology · 2024Review
- Effect of Ylang-Ylang (Molecules (Basel, Switzerland) · 2022Article
- Plant lectins as potent Anti-coronaviruses, Anti-inflammatory, antinociceptive and antiulcer agents.Saudi journal of biological sciences · 2022Review
- Anti-inflammatory and antinociceptive activities ofBiochimie open · 2016Article
- Gu-4 suppresses affinity and avidity modulation of CD11b and improves the outcome of mice with endotoxemia and sepsis.PloS one · 2012Article
- Purification of a lectin from Arisaema erubescens (Wall.) Schott and its pro-inflammatory effects.Molecules (Basel, Switzerland) · 2011Article
- 5-Lipoxygenase-deficient mice infected with Borrelia burgdorferi develop persistent arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo study and characterize the in vivo effect of the lectin from Luetzelburgia auriculata seed on acute inflammation models.
methodsThe lectin was purified from the crude saline extract by affinity chromatography on a guar-gum matrix. Native, heat-treated, and digested lectin was evaluated for anti-inflammatory activity by using peritonitis and paw edema models. The anti-inflammatory activity was characterized by intravital microscopy, nitric oxide production, and myeloperoxidase activity.
resultsThe lectin exhibited anti-inflammatory activity (2 mg/kg) on both models, reducing local myeloperoxidase activity. Galactose or heat treatment (100 degrees C, 10 min) reduced anti-inflammatory action. Anti-inflammation involves the inhibition of adhesion and rolling of leukocytes along with augmentation of nitric oxide in serum. The lectin inhibited the edematogenic effect of histamine and prostaglandins (PGE2) but did not alter the chemoattractant effect of IL-8.
conclusionsThe results indicate that this lectin is a potent anti-inflammatory molecule. Its effects engage diverse modulatory events.
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