Evidence map›Paper›PMID 19757077›Full record

ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2010

Defining larger roles for "tiny" RNA molecules: role of miRNAs in neurodegeneration research.

Sowmya V Yelamanchili, Howard S Fox

Open access · greenAbstract readReview
In one paragraph

Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Light at night: effect on the daily clock, learning, memory, cognition, and expression of transcripts in different brain regions of rat.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Up-regulation of microRNA-142 in simian immunodeficiency virus encephalitis leads to repression of sirtuin1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013
    Article
  15. Article
  16. Translating the brain transcriptome in neuroAIDS: from non-human primates to humans.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012
    Review
  17. MicroRNAs and Multiple Sclerosis.Autoimmune diseases · 2010
    Article
  18. MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2010
    Review
  19. Advances in the "omics" for diagnosis, pathogenesis, and therapeutic development.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sowmya V YelamanchiliDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Howard S Fox
University of Nebraska Medical Center · US

Funding

Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 2000 to 2021
$37.7M
Molecular Aspects of CNS Dysfunction Due to SIV/HIVR01MH073490 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FOX, HOWARD S · 2005 to 2014
$3.9M
Proteomic Strategies for AIDS and Drug Abuse - HIV and METH CNS SynergyP01DA026146 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 2008 to 2010
$2.9M
NIDA NIH HHS P01 DA026146NIMH NIH HHS P30 MH062261NIMH NIH HHS R01 MH073490
6 · The paper itself

Abstract

Many facets of transcriptional and translational regulation contribute to the proper functioning of the nervous system. Dysfunctional control of mRNA and protein expression can lead to neurodegenerative conditions. Recently, a new regulatory control element--small noncoding RNAs--has been found to play a significant role in many physiologic systems. Here, we review the microRNA (miRNA) field as it pertains to discovery-based and mechanistic studies on the brain and specifically in neurodegenerative disorders. Understanding the role of miRNAs in the brain will aid to open new avenues to the field of neuroscience and, importantly, neurodegenerative disease research.

Indexed as

AnimalsBrainGene Expression ProfilingGene Expression RegulationHumansMicroRNAsNerve DegenerationNeurodegenerative DiseasesOligonucleotide Array Sequence AnalysisMicroRNAs

Identifiers

PMID19757077
PMCPMC2881294
OpenAlexW2043198770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.