ArticleAnnals of biomedical engineering2009
A conductivity approach to measuring fixed charge density in intervertebral disc tissue.
Article in Annals of biomedical engineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Harnessing piezoelectric stimulation to modulate PI3K-AKT signaling for intervertebral disc regeneration.Bioactive materials · 2026Article
- An experimental-computational approach for measuring charged solute diffusivity through human synovium.Journal of biomechanics · 2025Article
- Article
- Characterizing baseline fixed charge density in human cervical intervertebral discs.Journal of biomechanics · 2025Article
- The role of loading-induced convection versus diffusion on the transport of small molecules into the intervertebral disc.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Regional structure-function relationships of lumbar cartilage endplates.Journal of biomechanics · 2024Article
- Non-enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content.JOR spine · 2024Article
- Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue.JOR spine · 2023Article
- Nanowarming and ice-free cryopreservation of large sized, intact porcine articular cartilage.Communications biology · 2023Article
- Patient-specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs.JOR spine · 2021Article
- Avidin grafted dextran nanostructure enables a month-long intra-discal retention.Scientific reports · 2020Article
- Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition.PloS one · 2019Article
- Electrical Conductivity Method to Determine Sexual Dimorphisms in Human Temporomandibular Disc Fixed Charge Density.Annals of biomedical engineering · 2018Article
- Article
- Evolution of osmotic pressure in solid tumors.Journal of biomechanics · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A new method for measuring the fixed charge density (FCD) in intervertebral disc (IVD) tissues employing a two-point electrical conductivity approach was developed. In this technique, the tissue is first confined and equilibrated in a potassium chloride (KCl) solution, and the tissue conductivity is then measured. This is then repeated with a second concentration of KCl solution. The FCD can be determined from the conductivity measurements. Using this method, the FCD values of bovine annulus fibrosus (AF) and nucleus pulposus (NP) tissues were determined to be 0.060 +/- 0.027 mEq/g wet tissue and 0.19 +/- 0.039 mEq/g wet tissue, respectively. The FCD of AF was significantly lower than that of NP tissue, similar to results in the literature for human IVD tissues. In order to verify the accuracy of the new method, the glycosaminoglycan (GAG) contents of the tissues were measured and used to estimate the tissue FCD. A strong correlation (R (2) = 0.84-0.87) was found to exist between FCD values measured and those estimated from GAG contents, indicating that the conductivity approach is a reliable technique for measuring the FCD of IVD tissues.
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