ArticleDigestive diseases and sciences2010
Proinflammatory Th2 cytokines induce production of thymic stromal lymphopoietin in human colonic epithelial cells.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- The molecular footprint of valproic acid in human hippocampal organoid.Molecular neurobiology · 2026Article
- Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Elucidating the Role of Innate and Adaptive Immune Responses in the Pathogenesis of Canine Chronic Inflammatory Enteropathy-A Search for Potential Biomarkers.Animals : an open access journal from MDPI · 2022Review
- Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease.Frontiers in immunology · 2022Review
- Type 2 immunity in intestinal homeostasis and inflammatory bowel disease.Biochemical Society transactions · 2021Review
- Changes in γδT Cells in Peripheral Blood of Patients with Ulcerative Colitis Exacerbations.Archivum immunologiae et therapiae experimentalis · 2021Article
- Role of myeloid-derived suppressor cells in the promotion and immunotherapy of colitis-associated cancer.Journal for immunotherapy of cancer · 2020Review
- Specific T-Cell Subsets Can Predict the Efficacy of Anti-TNF Treatment in Inflammatory Bowel Diseases.Archivum immunologiae et therapiae experimentalis · 2020Article
- The clarified role of interleukin-19 in the inflammatory bowel disease and hypersensitivity: Insights from animal models and humans.The Journal of veterinary medical science · 2019Review
- Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- The Role of T-Cell Subsets in Chronic Inflammation in Celiac Disease and Inflammatory Bowel Disease Patients: More Common Mechanisms or More Differences?Inflammatory intestinal diseases · 2016Review
- Evaluation of thymic stromal lymphopoietin (TSLP) and its correlation with lymphatic metastasis in human gastric cancer.Medical oncology (Northwood, London, England) · 2015Article
- Food allergy in mice is modulated through the thymic stromal lymphopoietin pathway.Clinical and translational allergy · 2015Article
- The biology of thymic stromal lymphopoietin (TSLP).Advances in pharmacology (San Diego, Calif.) · 2013Review
- Activated human nasal epithelial cells modulate specific antibody response against bacterial or viral antigens.PloS one · 2013Article
- Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13.Journal of gastroenterology · 2012Article
- The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond.Journal of leukocyte biology · 2012Review
- The regulation of thymic stromal lymphopoietin in gut immune homeostasis.Digestive diseases and sciences · 2011Review
- TSLP enhances the function of helper type 2 cells.European journal of immunology · 2011Article
- Helicobacter pylori promotes the production of thymic stromal lymphopoietin by gastric epithelial cells and induces dendritic cell-mediated inflammatory Th2 responses.Infection and immunity · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThymic stromal lymphopoietin (TSLP) is released by intestinal epithelial cells (IECs), and TSLP-conditioned dendritic cells appear to be involved in immune homeostasis of intestine and immunoglobulin A (IgA) class-switching in the physiological condition. In contrast, TSLP activates dendritic cells to induce strong T-cell proliferation and is involved in inflammatory T helper (Th) 2 responses in human allergic diseases. However, it is not clear how TSLP production by IECs is regulated in ulcerative colitis (UC), which appears to involve inflammatory Th2 responses. The aim of this study is to examine how TSLP production by IECs is regulated in ulcerative colitis.
resultsWe show here that expression of TSLP was enhanced in mucosal lesions from UC patients in which inflammatory Th2 cytokine production was predominant. In addition, using a human colonic epithelial cell line, we demonstrated that a combination of tumor necrosis factor-alpha (TNF-alpha) and interleukin-4 (IL-4) induced TSLP expression and that TSLP expression by TNF-alpha + IL-4 was further enhanced by either Toll-like receptor 3 ligand or interferon (IFN)-gamma.
conclusionsTaken together, as in human allergic diseases, an inflammatory Th2 condition in the mucosal lesions of UC patients may trigger increased TSLP expression by IECs, resulting in exacerbation of UC.
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