ArticleNeurochemical research2010
SSeCKS is a suppressor in Schwann cell differentiation and myelination.
Article in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- The Hidden Hand in White Matter: Pericytes and the Puzzle of Demyelination.ACS pharmacology & translational science · 2024Review
- Role of A-Kinase Anchoring Protein 12 in the Central Nervous System.Journal of clinical neurology (Seoul, Korea) · 2023Review
- A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter.Stem cells (Dayton, Ohio) · 2018Article
- Molecular Mechanisms Involved in Schwann Cell Plasticity.Frontiers in molecular neuroscience · 2017Review
- CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush.Molecular neurobiology · 2016Article
- Upregulation of KPNβ1 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- PFTK1 Promotes Gastric Cancer Progression by Regulating Proliferation, Migration and Invasion.PloS one · 2015Article
- Methylcobalamin promotes the differentiation of Schwann cells and remyelination in lysophosphatidylcholine-induced demyelination of the rat sciatic nerve.Frontiers in cellular neuroscience · 2015Article
- Involvement of upregulated SYF2 in Schwann cell differentiation and migration after sciatic nerve crush.Cellular and molecular neurobiology · 2014Article
- Transcription initiation factor IIB involves in Schwann cell differentiation after rat sciatic nerve crush.Journal of molecular neuroscience : MN · 2013Article
- Temporal-spatial expressions of Spy1 in rat sciatic nerve after crush.Cellular and molecular neurobiology · 2013Article
- Changes in the BAG1 expression of Schwann cells after sciatic nerve crush.Journal of molecular neuroscience : MN · 2013Article
- Negative regulators of schwann cell differentiation-novel targets for peripheral nerve therapies?Journal of clinical immunology · 2013Review
- Changes of peroxisome proliferator-activated receptor-γ on crushed rat sciatic nerves and differentiated primary Schwann cells.Journal of molecular neuroscience : MN · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Src-suppressed protein kinase C substrate (SSeCKS) plays an important role in the differentiation process. In regeneration of sciatic nerve injury, expression of SSeCKS decreases, mainly in Schwann cells. However, the function of SSeCKS in Schwann cells differentiation remains unclear. We observed that SSeCKS was decreased in differentiated Schwann cells. In long-term SSeCKS-reduced Schwann cells, cell morphology changed and myelin gene expression induced by cAMP was accelerated. Myelination was also enhanced in SSeCKS-suppressed Schwann cells co-culture with dorsal root ganglion (DRG). In addition, we found suppression of SSeCKS expression promoted Akt serine 473 phosphorylation in cAMP-treated Schwann cells. In summary, our data indicated that SSeCKS was a negative regulator of myelinating glia differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.