Trial reportAIDS and behavior2010
Acceptability of UC781 gel as a rectal microbicide among HIV-uninfected women and men.
Trial report in AIDS and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Acceptability of potential rectal microbicide delivery systems for HIV prevention: a randomized crossover trial.AIDS and behavior · 2013Trial
- Trial
- Overcoming COVID-19 disruptions: Innovations in product provision in a multi-national clinical trial among cisgender men, transgender men and transgender women in five countries.Contemporary clinical trials communications · 2022Article
- Article
- On-demand microbicide products: design matters.Drug delivery and translational research · 2017Review
- Lubricant Provides Poor Rectal Mucosal HIV Coverage.AIDS research and human retroviruses · 2017Article
- Lessons for Rectal Microbicide Development From an Acceptability Trial of a Placebo Gel Applied Prior to Receptive Anal Intercourse.Archives of sexual behavior · 2017Article
- Hypothetical Rectal Microbicide Acceptability and Factors Influencing It among Men Who Have Sex with Men in Tianjin, China.PloS one · 2016Article
- Assessing the potential of the Woman's Condom for vaginal drug delivery.Contraception · 2015Article
- The rational design and development of a dual chamber vaginal/rectal microbicide gel formulation for HIV prevention.Antiviral research · 2015Article
- Sexual behaviors and partner-specific correlates of heterosexual anal intercourse among truck drivers and their wives in South India.Archives of sexual behavior · 2015Article
- Rectal-specific microbicide applicator: evaluation and comparison with a vaginal applicator used rectally.AIDS and behavior · 2014Article
- Preparing for rectal microbicides: sociocultural factors affecting product uptake among potential South American users.American journal of public health · 2014Article
- Article
- Rectal microbicide development.Current topics in microbiology and immunology · 2014Review
- A social ecology of rectal microbicide acceptability among young men who have sex with men and transgender women in Thailand.Journal of the International AIDS Society · 2013Article
- Shape of vaginal suppositories affects willingness-to-try and preference.Antiviral research · 2013Article
- Rectal microbicide development.Current opinion in HIV and AIDS · 2012Review
- Microbicides for HIV prevention.The Indian journal of medical research · 2011Review
- Rectal microbicides: can we make them and will people use them?AIDS and behavior · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
We studied the overall acceptability of UC781 gel formulation when applied rectally. Ten women and twenty-six men, all HIV-uninfected, were enrolled in a Phase 1, randomized, blinded, placebo-controlled safety and acceptability study of the vaginal microbicide gel UC781 applied rectally. Participants were randomized to three groups: 0.1% UC781 gel, 0.25% UC781 gel, or a placebo gel. Acceptability was assessed using structured questionnaires and qualitative in-depth interviews. After using UC781 gel rectally for seven consecutive days, participants' reports suggest that a UC781 gel formulation is highly acceptable and comparable to a placebo gel. The gels received favorable ratings overall and on attributes such as color, smell and consistency. All of the participants reported high intentions to use a gel like the one they used in this study. Acceptability research is essential in early phases of microbicide development to identify potential problems, understand user preferences, and introduce changes if needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.