ArticleObesity surgery2009
A surgical rat model of sleeve gastrectomy with staple technique: long-term weight loss results.
Article in Obesity surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mesenchymal Stem Cells and PRP Therapy Favorize Leak Closure After Sleeve Gastrectomy in Zucker Rats.Obesity surgery · 2022Article
- VERTICAL GASTRECTOMY VS. EXTENDED VERTICAL GASTRECTOMY: WHAT IS THE IMPACT ON GASTROESOPHAGEAL REFLUX DISEASE IN OBESE RATS?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2020Article
- Gastric Plication and Sleeve Gastrectomy in an Experimental Model of Obesity: New Insights into Weight Loss, Intake and Metabolic Results.Obesity surgery · 2018Article
- Hematological, Biochemical, and Immunological Laboratory and Histomorphological Effects of Sleeve Gastrectomy on Female Rats.The Indian journal of surgery · 2015Article
- Sleeve Gastrectomy Reduces Hepatic Steatosis by Improving the Coordinated Regulation of Aquaglyceroporins in Adipose Tissue and Liver in Obese Rats.Obesity surgery · 2015Article
- Surgical models of Roux-en-Y gastric bypass surgery and sleeve gastrectomy in rats and mice.Nature protocols · 2015Article
- Sleeve gastrectomy and gastric plication in the rat result in weight loss with different endocrine profiles.Obesity surgery · 2013Article
- Sleeve gastrectomy and Roux-en-Y gastric bypass exhibit differential effects on food preferences, nutrient absorption and energy expenditure in obese rats.International journal of obesity (2005) · 2012Article
- Short-term effects of sleeve gastrectomy and caloric restriction on blood pressure in diet-induced obese rats.Obesity surgery · 2012Article
- Sleeve gastrectomy reduces blood pressure in obese (fa/fa) Zucker rats.Obesity surgery · 2012Article
- Experimental metabolic surgery: justification and technical aspects.Obesity surgery · 2011Article
- Sleeve gastrectomy induces weight loss in diet-induced obese rats even if high-fat feeding is continued.Obesity surgery · 2011Article
- Long-term plasma ghrelin and leptin modulation after sleeve gastrectomy in Wistar rats in comparison with gastric tissue ghrelin expression.Obesity surgery · 2011Article
- Article
- Metabolic effects of sleeve gastrectomy in female rat model of diet-induced obesity.Surgery for obesity and related diseases : official journal of the American Society for Bariatric SurgeryArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleeve gastrectomy (SG) is one of the surgical procedures applied for treating morbid obesity consisting of removing the gastric fundus and transforming the stomach into a narrow gastric tube. The aim of this experimental study is to create a functional model of SG and to present the long-term weight loss results.
methodsTwenty adult Wistar rats were fed with high fat diet for 12 weeks before being divided randomly in two groups of ten rats each. One group underwent SG performed with the use of staples, and the other group underwent a sham operation (control group). The animals' weight was evaluated weekly for 15 weeks after the operation.
resultsAll animals survived throughout the experiment. After the operation both groups started to lose weight with maximum weight loss on the seventh postoperative day (POD) for the sham-operated group and on the 15th POD for the SG group. Thereafter, both groups started to regain weight but with different rates. By the fourth postoperative week (POW), the average weight of the sham group did not differ statistically significantly compared to the preoperative weight, while after the eighth POW, rats' average weight was statistically significantly increased compared to the preoperative value. On the other hand, average weight of the SG group was lower postoperatively until the end of the study compared to the preoperative average weight.
conclusionWe have created a surgical rat model of experimental SG model, enabling the further study of biochemical and hormonal parameters.
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